Combining methotrexate and tofacitinib for rheumatoid arthritis
Treatments studied
Part of Bones, joints & muscles, Immune system & allergy, Skin clinical trials.
This study tests whether combining two medicines—methotrexate and tofacitinib—works better for people with a specific type of rheumatoid arthritis. It may be a good fit if you have moderate to severe arthritis, have had a joint biopsy that shows a certain cell pattern, and haven't used similar treatments before.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have moderate to severe rheumatoid arthritis (confirmed by a doctor using standard criteria).
- You have had a biopsy of your joint lining showing a specific cell pattern (myeloid-stromal) that may respond better to this combination.
- You have not taken strong immune-suppressing drugs (biologics or JAK inhibitors) before starting this study.
- You do not have serious health problems like uncontrolled infections, heart failure, blood clots, or certain cancers.
- You are willing to follow the study plan and sign a consent form.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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