Personalized therapy and antidepressants for depression
Treatments studied
Part of Mental health clinical trials.
This trial studies whether a personalized combination of talk therapy (CBT) and antidepressant medication works better for people with moderate to severe depression. It’s meant to match treatment choices to your situation and to see what helps most.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with major depressive disorder or persistent depressive disorder as the main problem
- Your depression is currently at least moderate (score 14 or higher on the 17-question Hamilton Depression Scale)
- Your depression has lasted at least 2 months (not just a brief first episode)
- You can understand and sign consent to take part
- You do not have bipolar disorder or a history of schizophrenia-spectrum disorders
- You are not pregnant and you have not had major recent changes: no new antidepressant in the last 12 weeks or dose change in the last 6 weeks, and no 10+ sessions of talk therapy in the past year
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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