Radiation after mastectomy for certain node-negative breast cancers
Part of Cancer, Skin clinical trials.
This trial studies whether giving radiotherapy after a mastectomy helps prevent breast cancer coming back in women whose lymph nodes are not involved (or only very tiny spread). It may help reduce recurrence risk, especially for patients with higher-risk features despite node-negative early cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have breast cancer that is stage pT1 or pT2 and has no spread to lymph nodes (N0) and no distant spread (M0)
- Your mastectomy was done first on one side, and the surgeon removed the tumor with clear margins (at least 1 mm away from invasive cancer or DCIS)
- You had axillary (underarm) node checking such as node clearance, sampling, or a sentinel node biopsy
- Your biggest tumor size is greater than 2 cm, OR you have a multifocal tumor where the overall measured size is greater than 2 cm
- You have at least one higher-risk feature (for T2: one risk; for T1: any listed risk such as high grade, lymph vessel invasion, ER/PR negative, HER2 positive, or age under 35)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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