Testing a half-matched bone marrow transplant for sickle cell
Part of Blood & lymphatic, Genetic & congenital clinical trials.
This early-phase study tests whether a “half-matched” donor bone marrow transplant, with special medicines to calm the immune system before transplant, can improve outcomes for people with sickle cell disease. It may help high-risk patients who have frequent complications and don’t have a fully matched donor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have sickle cell anemia (Hgb SS or S/B thalassemia).
- Your baseline hemoglobin level is above 60% (as measured in clinic labs).
- You are likely high-risk due to things like stroke/TIA or abnormal brain blood-flow test, frequent acute chest syndrome, severe pain crises, recurrent priapism, or joint bone damage (osteonecrosis).
- Your age is 1 to 30 years.
- You must have a related donor who is “half-matched” for key tissue types (HLA-A, B, C, DRB1), and no fully matched sibling or fully matched (10/10) unrelated donor is available.
- You must not have an uncontrolled infection, active cancer (except non-melanoma skin cancer), be pregnant, or have had a prior transplant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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