Clinical trials
Sickle Cell Disease clinical trials
Below are recruiting sickle cell disease clinical trials, each written for real people, not researchers. We’re tracking 171 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06975865RecruitingPhase 3
Rilzabrutinib for sickle-cell disease pain episodes
This study tests an oral medicine called rilzabrutinib to see if it can reduce painful episodes in people with sickle-cell disease. It may be an option if you have regular pain crises and are looking for a new treatment.
Birmingham, AlabamaAges 10–65 - NCT05392894RecruitingPhase 3
Transplant using a half-matched donor for severe sickle cell
This trial tests whether a half-matched (haploidentical) blood stem cell transplant can treat adults with severe sickle cell disease. It may help reduce serious complications and improve survival, but it requires a fit health status and specific donor and medical conditions.
LondonAges 18 years+ - NCT04201210RecruitingPhase 2
Stem cell transplant study for young people with severe sickle cell
This Phase 2 study tests a type of stem cell transplant that uses donor immune cells that have been specially “tweaked” to help treat sickle cell disease. It may help prevent serious sickle cell complications, but it requires careful matching and screening of organs and pregnancy status.
ViennaAges 2–35 - NCT03786549Recruiting
Sickle cell care transition program for teens and families
This study tests a structured program to help teens with sickle cell disease smoothly transition from pediatric care to adult care, with support for parents or legal guardians. It may help families coordinate care sooner and more confidently during this change.
Fort-de-France-La Martinique, La MartiniqueAges 16–17 - NCT07800247Recruiting
Sickle cell disease registry for young patients
This study collects information about children, teens, and young adults with sickle cell disease to better understand the condition in Egypt. It may help improve care and treatments for people with sickle cell disease.
CairoAges Up to 39 years - NCT07753681Recruiting
Chronic disease care in Zambia
This study helps improve care for people with long-term illnesses like diabetes or high blood pressure in Zambia. It aims to make sure you get regular check-ups and support.
Lusaka, Lusaka ProvinceAges Any age - NCT07708714RecruitingPhase 1/Phase 2
Hydroxyurea study for teens with sickle cell anemia
This study tests how well a higher dose of hydroxyurea works for teenagers with sickle cell anemia living in areas where malaria is common. It looks at safety and how the treatment affects their daily lives.
KampalaAges 11–18 - NCT06399107RecruitingPhase 1/Phase 2
Gene therapy trial for sickle cell disease using BAH243
This trial tests a gene therapy that uses a modified virus to deliver a healthy gene to your blood stem cells. It aims to help people with sickle cell disease produce normal red blood cells and reduce painful crises.
Beijing, Beijing MunicipalityAges 2–90 - NCT07656415RecruitingPhase 3
Study of mitapivat for sickle cell disease patients who need blood transfusions
This study tests whether a daily pill called mitapivat can reduce the number of blood transfusions you need. It is for people with sickle cell disease who have had at least one transfusion in the past year and are not on regular transfusion therapy.
Indianapolis, IndianaAges 12 years+ - NCT07616154RecruitingPhase 2
Gene-Matched Family Stem Cell Transplant for Severe Sickle Cell
This trial tests whether a stem cell transplant from a partially gene-matched family member can cure severe sickle cell disease in children and young adults. The transplant uses a new approach that may work even when a perfectly matched sibling isn't available, and it might help patients whose sickle cell is causing serious complications like strokes, organ damage, or frequent pain crises.
Memphis, TennesseeAges Up to 22 years - NCT07610239Recruiting
Newborn Sickle Cell Disease Screening System in Uganda
This study tests a new computer system to help hospitals quickly identify babies with sickle cell disease (an inherited blood disorder) right after birth or at early health visits. Finding sickle cell disease early helps prevent serious health problems and saves lives.
JinjaAges 18 years+ - NCT07599176RecruitingPhase 1/Phase 2
Partial stem cell transplant for sickle cell disease from matched donors
This study tests a partial stem cell transplant from a matched donor to treat sickle cell disease. It may help reduce complications like strokes, organ damage, or pain crises.
Bethesda, MarylandAges 4–65 - NCT07566494RecruitingPhase 1
Testing VAS-101 for sickle cell disease
This early-phase trial tests a new drug called VAS-101 for people with sickle cell disease. It aims to find a safe dose and see how the drug affects the body.
Bethesda, MarylandAges 18–90 - NCT07562451Recruiting
How Music Therapy Affects Pain in Young People With Sickle Cell Disease
This study explores whether listening to music can help reduce chronic pain in young people with sickle cell disease. Researchers will use blood tests to understand how music affects your body's cells and your pain levels.
Atlanta, GeorgiaAges 8–18 - NCT06757829Recruiting
Lung function in sickle cell: testing Acu-TENS therapy
This study tests if a gentle electrical nerve stimulation treatment (called Acu-TENS) can help improve your lung function. It's for people with sickle cell disease who are not currently in pain or have other major health issues.
Dokki, Giza GovernorateAges 20–50 - NCT05099874Recruiting
Computer training to improve attention in sickle cell disease
This trial tests whether a computer-based “attention control” training program can improve attention and daily functioning in children with sickle cell disease. To join, you must meet certain criteria and also pass an initial attention screening test during the study.
Washington D.C., District of ColumbiaAges 8–16 - NCT07488520RecruitingPhase 4
Early sickle cell testing for newborns
This study tests a simple blood test for newborn babies to find sickle cell disease early. If the test shows your baby has it, they can get care right away to stay healthier.
AbidjanAges birth–6 months - NCT07488091Recruiting
Sickle cell pregnancy care program in Ghana
This trial tests a team-based care program for pregnant women with sickle cell disease. It aims to improve health for both mothers and babies through regular checkups and support.
AccraAges 18–45 - NCT03327428Recruiting
Registry study for people with sickle cell disease
This study is a registry that collects information about people living with sickle cell disease. It may help researchers better understand sickle cell types in Germany, Austria, and Switzerland and support future research and care.
Heidelberg, Baden-WurttembergAges birth–100 years - NCT07432867RecruitingPhase 1/Phase 2
Gene therapy for severe sickle cell disease in teens and adults
This trial tests a new gene therapy for sickle cell disease. It uses your own blood stem cells (collected from bone marrow) that are modified in a lab to help produce healthy red blood cells, then given back to you after a short chemotherapy. The goal is to reduce or stop severe complications like pain crises and lung problems.
Paris, Île-de-France RegionAges 12–35 - NCT06823219Recruiting
Long-term endurance training for sickle cell disease
This study tests whether a long-term endurance exercise program can improve physical fitness, reduce complications, and enhance quality of life for people with sickle cell disease. It is designed for patients whose condition is stable but who have had at least one pain crisis in the last three years.
CréteilAges 15 years+ - NCT06770010Recruiting
Digital brain training for kids with sickle cell disease
This trial is testing a digital program to help improve working memory (the ability to hold and use information in your mind) for children with sickle cell disease. If you join, you'll use a computer-based training program at home and researchers will see if it works and is easy to use.
Washington D.C., District of ColumbiaAges 7–16 - NCT07392216Recruiting
Ovarian health in young women with sickle cell disease
This study looks at how sickle cell disease might affect the ovaries (the organs that store eggs) in girls and young women. It compares participants with sickle cell disease to healthy females of similar age and background.
Memphis, TennesseeAges 10–18 - NCT07369024RecruitingPhase 2
Study of low-dose ketamine for sickle cell pain crisis
This study tests whether a low-dose of ketamine (a pain medicine) can help children and young adults with sickle cell disease who are in a pain crisis. It aims to provide better pain relief while avoiding some side effects of standard painkillers.
Torrance, CaliforniaAges 5–20
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Sickle Cell Disease trials by city
Studies with a site in or near these metro areas.
Sickle Cell Disease trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for sickle cell disease?
- Yes. Clin2 currently lists 171 recruiting sickle cell disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sickle cell disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sickle cell disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.