Stem cell treatment for spinocerebellar ataxia walking problems
Treatments studied
Part of Brain & nervous system, Genetic & congenital clinical trials.
This Phase 2 study tests an umbilical cord “stem cell” treatment to improve symptoms in people with spinocerebellar ataxia (a nerve condition that affects balance and walking). It may help walking ability and overall ataxia symptoms, but you must meet specific health and lab safety checks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of spinocerebellar ataxia (including SCA1, SCA2, SCA3, or SCA6) or SARA scoring that falls in the mild range (SARA score 2–5).
- You can complete an 8-meter walking test (8MW).
- You have not received any stem cell treatment in the past 6 months.
- Your blood tests are high enough (white blood cells, platelets, and hemoglobin meet study minimums).
- You do not have serious infection (such as pneumonia), or major heart, kidney, or liver problems or unsafe liver/pregnancy-related lab results.
- You cannot be pregnant or breastfeeding, and you must not be in another clinical study in the past 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests if deep brain stimulation (putting a device in the brain to send mild electrical pulses) can improve balance and movement in people with spinocerebellar ataxia type 6 (SCA6), a genetic condition that causes trouble walking and coordination.
This trial tests a non-invasive brain stimulation method called transcranial temporal interference stimulation to see if it can improve symptoms of spinocerebellar ataxia type 3 (a condition affecting balance and coordination). It aims to find the best stimulation settings to help with movement and gait.
This study follows people with certain types of spinocerebellar ataxia (a group of conditions that cause progressive movement problems) to understand how the disease changes over time and how genes might influence it. It may help researchers learn more about these conditions and support future treatments.
This trial tests a stem cell therapy called Stemchymal® for people with a specific type of hereditary ataxia (SCA3). It aims to see if the treatment can improve balance and coordination.
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