Treatment
Intrathecal clinical trials
We’re tracking 104 recruiting studies that include Intrathecal, each written for real people, not researchers, below.
Recruiting studies
- NCT06099366RecruitingPhase 2
Chemo for standard-risk childhood leukemia
This trial tests a treatment plan for children with newly diagnosed acute lymphoblastic leukemia (ALL) that is considered standard-risk. It aims to see if the treatment is effective and safe.
Seoul, Other (Non U.s.)Ages 1–9 - NCT07387926RecruitingPhase 1/Phase 2
Testing asciminib for children and young adults with a type of leukemia
This trial tests an experimental drug called asciminib for children and young adults whose leukemia (a specific type of B-cell acute lymphoblastic leukemia with certain gene changes) has come back or not responded to treatment. The goal is to see if the drug is safe and effective for these patients.
Ramat GanAges 1–30 - NCT06837844Recruiting
Pain relief study for knee replacement surgery
This trial tests a combination of two pain-relief methods after total knee replacement: a spinal injection and a nerve block in the thigh. It aims to provide better pain control during and after surgery.
Kafr ash Shaykh, KafrelsheikhAges 18–75 - NCT06636864Enrolling by invitation
Morphine injection for better recovery after colon cancer surgery
This trial tests if giving a single injection of morphine into the spinal fluid can improve how well you feel and recover after laparoscopic surgery for colorectal cancer. The morphine is given through a spinal needle before surgery, and it may help control pain during and after the procedure.
Guangzhou, GuangdongAges 18 years+ - NCT07170267Recruiting
Pain relief study for cesarean section
This study tests whether a nerve block in the lower belly wall (transversalis fascia plane block) or a medication injected into the spinal fluid (intrathecal dexmedetomidine) provides better pain relief for mothers having a planned cesarean section under spinal anesthesia.
Tanta, El-GharbiaAges 18–40 - NCT07629323Enrolling by invitation
Spinal Pain Relief During Hiatal Hernia Surgery
This trial tests whether injecting pain medication directly into the spinal fluid during a minimally invasive stomach surgery (called fundoplication) helps reduce pain after the operation. Fundoplication is used to treat severe acid reflux.
Karlstad, Värmland CountyAges 18 years+ - NCT07050277RecruitingPhase 3
Morphine for bladder issues after knee replacement
This study tests whether adding morphine to spinal anesthesia can reduce trouble urinating after a second knee replacement surgery. It may help you avoid needing a catheter after surgery.
Toronto, OntarioAges 21 years+ - NCT07691840Recruiting
Intrathecal therapy vs. standard care for severe cancer pain
This trial compares a treatment that delivers pain medicine directly to the spinal cord (intrathecal therapy) with usual pain control. It is for people with severe cancer pain that is not helped by oral or intravenous opioids.
JetteAges 18 years+ - NCT07092202RecruitingPhase 4
Firmonertinib and spinal injection for EGFR lung cancer with spread to brain lining
This trial tests combining a targeted pill (firmonertinib) with medication injected into the fluid around the spine for people with a specific type of lung cancer that has spread to the lining of the brain. It may offer a new option if you have already tried other EGFR drugs and are still having progression.
Wuhan, HubeiAges 18 years+ - NCT07540104Recruiting
Pain block vs morphine injection for chest surgery
This study compares two ways to manage pain after video-assisted chest surgery (VATS): a numbing injection near the shoulder blade (serratus posterior superior intercostal plane block) versus a small dose of pain medicine in the spine (intrathecal morphine). The goal is to find which approach works better and has fewer side effects.
Atakent, SamsunAges 18–75 - NCT02657785RecruitingPhase 2/Phase 3
Treating newly diagnosed brain lymphoma with added medicines into CSF
This trial studies a treatment plan for people with newly diagnosed non-Hodgkin lymphoma that has spread to the brain and covering tissues (meninges). It combines medicines given through the bloodstream with immunotherapy placed into the fluid around the brain (CSF) to improve control of the lymphoma.
Beijing, Beijing MunicipalityAges 18–75 - NCT02836158RecruitingPhase 2/Phase 3
Test drug plus spinal chemotherapy for older PCNSL
This trial studies whether adding R-IDARAM and medication delivered into the spinal fluid can improve treatment for primary central nervous system lymphoma (PCNSL) in newly diagnosed older adults. It may help by targeting lymphoma cells in the brain, covering membranes, and spinal fluid.
Beijing, Beijing MunicipalityAges 60–75 - NCT06775431RecruitingPhase 3
Comparing two drugs to prevent shivering during C-section
This trial tests two ways of giving a medicine (pethidine) to prevent shivering during a C-section with spinal anesthesia. It aims to find which method works better.
Alexandria, Alexandria GovernorateAges 20–40 - NCT07263425RecruitingPhase 2
Study of thiotepa and trastuzumab for breast cancer that spread to the lining of the brain and spinal cord
This trial tests a combination of two drugs given through a special port in the head to treat HER2-positive breast cancer that has spread to the layer covering the brain and spinal cord (leptomeningeal metastasis). It aims to see if this treatment is safe and effective.
Nanjing, JiangsuAges 18–75 - NCT07744529RecruitingPhase 1/Phase 2
Combination treatment for lung cancer spread to the lining of the brain
This trial tests a new combination of two drugs for people with a specific type of lung cancer that has spread to the lining of the brain and spinal cord. The treatment aims to target the cancer cells and may help improve symptoms and survival.
Hangzhou, ZhejiangAges 18 years+ - NCT06543992RecruitingPhase 2
Chemotherapy for breast cancer that spread to the brain lining
This trial tests a combination of two chemotherapy drugs (thiotepa and methotrexate) given directly into the fluid around your brain and spine through a small implanted device. It aims to treat breast cancer that has spread to the lining of the brain or spinal cord.
Nanjing, JiangsuAges 18–75 - NCT07522736Recruiting
Spinal anesthesia with dexmedetomidine for knee surgery
This trial tests adding dexmedetomidine (a calming medication) to bupivacaine (numbing medication) injected into the spine during knee surgery. The goal is to improve pain relief and recovery after surgery.
CairoAges 18–65 - NCT07231926Recruiting
Spinal morphine for recovery after keyhole lung surgery
This trial tests whether giving a small dose of morphine into the fluid around the spinal cord (intrathecal) can improve pain relief and recovery after keyhole lung surgery. It aims to help patients feel better faster and have fewer complications.
ErzurumAges 18–70 - NCT07727798Recruiting
Pump refill for pain: at home vs hospital
This trial compares filling your implanted pain pump at home versus at the hospital. It helps researchers see if home refills are just as safe and convenient.
JetteAges 18 years+ - NCT07720739Recruiting
Adding morphine to a spine block for belly surgery pain
This study tests whether adding a small dose of morphine to a numbing injection near the spine (called erector spinae plane block) provides better pain relief after midline belly surgery. It may help reduce the need for other pain medicines and improve recovery.
SohagAges 18–60 - NCT05257018RecruitingPhase 2
Chemo plus medicine in the spine to prevent lymphoma brain relapse
This Phase 2 study tests whether adding intrathecal methotrexate (a cancer drug delivered into the spinal fluid) to standard chemo can lower the risk of diffuse large B-cell lymphoma (DLBCL) coming back in the brain or spinal fluid. It is for people with higher-than-usual risk of central nervous system (CNS) relapse.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06230055RecruitingPhase 4
Chemotherapy for breast cancer that has spread to the spinal fluid
This trial tests a chemotherapy drug given directly into the spinal fluid for people with HER2-negative breast cancer that has spread to the lining of the brain and spinal cord (called leptomeningeal metastasis). It may help when standard treatments have stopped working or caused too many side effects.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06317870Recruiting
Nerve block vs spinal morphine for hip surgery pain
This trial compares two types of pain relief after a hip replacement: a nerve block (injecting numbing medicine near the hip) versus a small dose of morphine given through a spinal needle. It aims to find out which option works better with fewer side effects.
Lausanne, Canton of VaudAges 18 years+ - NCT07695935Recruiting
Pain relief after hernia repair: nerve block vs low-dose morphine
This study compares two ways to manage pain after open inguinal hernia repair: a nerve block (injection near the abdominal muscles) versus a low-dose painkiller (morphine) given through the spinal needle. The goal is to find which method provides better relief with fewer side effects.
ÇorumAges 18–80
What Intrathecal is being studied for
Conditions with recruiting Intrathecal studies.
Common questions
- Are there clinical trials studying Intrathecal?
- Yes. Clin2 currently lists 104 recruiting studies that include Intrathecal, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Intrathecal trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Intrathecal an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Intrathecal or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.