Stem cell injection for moderate knee osteoarthritis pain
Part of Bones, joints & muscles clinical trials.
This Phase 2 study tests whether injected umbilical-cord stem cells can improve safety and reduce symptoms in people with moderate knee osteoarthritis. It focuses on people with significant knee pain who have not gotten enough relief from standard, non-procedure treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have knee osteoarthritis graded as 2 to 3 (moderate) on an X-ray scoring system called Kellgren-Lawrence.
- Your knee cartilage has injury seen on an MRI (for example partial or full-thickness cartilage damage).
- You are under 70 years old and generally medically stable (no serious organ problems or unstable breathing/blood pressure/heart rate).
- Your knee pain has lasted over 2 years or did not respond well to conservative treatments, and your pain score is 4 or higher out of 10.
- You should have normal liver and kidney blood tests, and no history of gout, rheumatoid arthritis, or autoimmune diseases, and you must agree to sign consent.
- You cannot be pregnant/breastfeeding, have a recent history of certain knee treatments (like steroid or hyaluronate injections), recent participation in other drug studies, serious infection, prior knee joint infection/surgery/radiation, or major uncontrolled health issues.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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