Clin2
NCT03511846Possibly a fitEnrolling by invitation

Pain biomarker study for headache or back nerve pain

MigraineCluster HeadacheTrigeminal Autonomic CephalgiaHemicrania ContinuaParoxysmal HemicraniaSUNCTShort-Lasting Unilateral Neuralgiform Headache With Conjunctival Injection and Tearing

Part of Brain & nervous system, Injuries & trauma clinical trials.

This study looks at measurable “pain signals” (biomarkers) in people with certain headache disorders or lumbar nerve pain, and compares them with healthy people. It may help researchers better understand what drives pain and how it can be detected.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
371 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 or older
  • You have one of these: migraine/tension/cluster or related headache syndromes, or a doctor-diagnosed lumbar radiculopathy, or you are a healthy control with no severe headache or back/nerve pain in the past 3 months
  • You can sign a HIPAA form allowing the study team to access your prior records and imaging
  • You do not have a history of major heart/brain blood-vessel problems, brain tumors, or epilepsy
  • You are not pregnant or breastfeeding, and you don’t currently smoke or use nicotine daily
  • You are able and willing to give informed consent, and you don’t have active substance use that would interfere with study visits

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT02910323Recruiting
Study for cluster headaches and trigeminal nerve pain

This study looks at people with certain severe headache disorders (cluster-type headaches or SUNCT/SUNA) or trigeminal neuralgia (sharp facial nerve pain). Researchers want to better understand these conditions and see how study testing/record review may help care.

Houston, Texas
NCT07514208Enrolling by invitation
Headache Sensitivity and Pain Testing Study

This study examines how sensitive the skin and tissues around the head are in people with migraines or tension headaches. Researchers will perform gentle touch and pressure tests to understand pain patterns, which may help improve headache treatment in the future.

Barcelona, Barcelona
NCT05752396Recruiting
Study of Pain Patterns Over Time in Kids

This study follows kids who have a specific type of chronic pain (headaches, stomach pain, or muscle/joint pain) to better understand how pain changes over time. It also checks whether certain factors are linked to those pain patterns.

Cincinnati, Ohio
NCT07812740Recruiting
A long-term study of rare headache disorders

This study is designed to learn more about a group of rare headache disorders called trigeminal autonomic cephalalgias (TACs). If you have one of these conditions, participating could help doctors better understand how they behave over time and improve care for others like you.

Milan, MI
NCT07567300Recruiting
Understanding Pain Patterns in Migraine and Neck or Back Pain

This study explores how migraine headaches, neck pain, and lower back pain may share similar pain mechanisms in the body. Researchers will ask you questions to understand your pain patterns and help identify connections between these conditions.

Gaziantep, Merkez
NCT06882278Not yet recruiting
Nerve block treatment for cluster headache episodes

This trial tests a procedure that uses targeted pulses of energy and a special blood-platelet solution to calm a specific nerve cluster at the back of the nose, which may reduce the frequency and intensity of cluster headache attacks. It is for people whose headaches have not improved enough with standard preventive medicines.

Beijing, Beijing Municipality

Hear when a new Migraine trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.