Nerve block treatment for cluster headache episodes
Part of Brain & nervous system clinical trials.
This trial tests a procedure that uses targeted pulses of energy and a special blood-platelet solution to calm a specific nerve cluster at the back of the nose, which may reduce the frequency and intensity of cluster headache attacks. It is for people whose headaches have not improved enough with standard preventive medicines.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have been diagnosed with episodic cluster headache and are currently in the first 5 days of a cluster period.
- You have had at least 2 prior cluster periods, with at least 4 attacks per week during usual bouts, and typical bouts lasting at least 4 weeks.
- Your headaches have not improved by more than half after trying standard preventive medicines such as verapamil, topiramate, lithium, or steroids.
- You have no serious medical conditions (like abnormal blood tests, heart or lung issues), no active infections at the procedure site, no history of mental illness or drug abuse, no problems with blood clotting, and are not pregnant or breastfeeding.
- You have not had prior invasive treatments like nerve destruction of the same area.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether injections of botulinum toxin type A can reduce frequent, severe cluster headache attacks by targeting a facial nerve area. It’s for people whose cluster headaches have not responded well—or have caused side effects—to standard preventive treatments.
This Phase 3 trial tests whether repeated injections can reduce attacks of chronic cluster headache. It may help people who have frequent, consistent attacks and can track them closely during the study.
This study looks at people with certain severe headache disorders (cluster-type headaches or SUNCT/SUNA) or trigeminal neuralgia (sharp facial nerve pain). Researchers want to better understand these conditions and see how study testing/record review may help care.
This study looks at measurable “pain signals” (biomarkers) in people with certain headache disorders or lumbar nerve pain, and compares them with healthy people. It may help researchers better understand what drives pain and how it can be detected.
This trial tests a treatment called sphenopalatine ganglion (SPG) pulsed radiofrequency for people with chronic cluster headache. It uses short bursts of energy to calm a nerve cluster in the face that is linked to the pain, and may help when standard medicines like verapamil or lithium haven't worked.
This study tests whether a nerve block injection near the neck (called stellate ganglion block), guided by ultrasound, can reduce chronic migraine pain. It may be a good option if you have chronic migraine and haven't found relief from standard preventive medications.
Hear when a new Cluster Headache trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.