Combination treatment for recurring brain cancer
Part of Cancer clinical trials.
This trial tests a combination of two drugs, bortezomib and temozolomide, for people whose brain tumor (glioblastoma) has returned after initial treatment. It's designed for tumors that don't respond well to standard treatments, and the goal is to see if this combination can help control the cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a confirmed diagnosis of glioblastoma that has come back after treatment.
- Your tumor must not have a certain genetic marker called MGMT methylation.
- You must have a tumor that can be measured on an MRI scan.
- Your overall health must be good enough for you to be up and about (Karnofsky score of 70 or higher).
- Your blood counts and liver/kidney function must be within acceptable ranges.
- You cannot have had certain previous treatments for this cancer, like bevacizumab or lomustine.
- You must not have significant heart disease or a recent heart attack or stroke.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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