Trimipramine, atezolizumab, and bevacizumab for recurrent glioblastoma
Treatments studied
Part of Cancer clinical trials.
This trial tests a combination of three drugs—trimipramine (an antidepressant), atezolizumab (an immunotherapy), and bevacizumab (a targeted therapy)—in people whose glioblastoma has come back after initial treatment. The goal is to see if this mix can help shrink the tumor or slow its growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have glioblastoma that has returned after standard treatment with radiation and temozolomide chemotherapy.
- You are at least 3 months past the radiation and chemotherapy part of your initial treatment.
- You are on a stable or decreasing dose of steroids for at least 7 days before the trial starts.
- Your brain tumor can be seen on an MRI and measures at least 10 millimeters in two directions.
- You have good overall health (able to do most daily activities) and adequate blood, liver, and kidney function.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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