Clin2
NCT03694236Possibly a fitRecruiting

Durvalumab with chemoradiation before lung tumor surgery

Potentially Resectable Stage II/IIIa NSCLC

Treatments studied

Part of Cancer, Lungs & breathing clinical trials.

This trial studies whether adding durvalumab (an immune therapy) to standard chemoradiation before surgery can improve outcomes for people with stage III, resectable lung cancer. It aims to help shrink the tumor and improve chances of successful treatment.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
39 people
Ages
20 years and older
Study type
Interventional

Who can take part

  • Have lung cancer confirmed on biopsy as non-small cell lung cancer (NSCLC)
  • Have stage III disease with involvement that may still be removable by surgery (including certain N2 nodes)
  • Be 20 years or older, and agree to sign consent forms before any study tests
  • Be able to do daily activities fairly well (ECOG 0 or 1)
  • Blood tests must be strong enough (for example hemoglobin ≥9, neutrophils ≥1500, platelets ≥100,000)
  • Heart/liver/kidney tests must meet limits, and you must have at least 6 months expected survival

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06998719Not yet recruiting· Phase 2
Immunotherapy and chemo before surgery for stage III lung cancer

This trial tests a combination of immunotherapy (durvalumab) and chemotherapy before surgery or radiation for people with stage III lung cancer that is on the edge of being removable. The goal is to shrink the tumor enough to allow surgery or more effective radiation.

Beijing, Beijing Municipality
NCT06284317Recruiting· Phase 3
Durvalumab after chemo and surgery for early lung cancer

This trial tests adding durvalumab (an immunotherapy) after chemotherapy, surgery, and more durvalumab for people with early-stage, operable non-small cell lung cancer. It aims to see if this extra treatment helps prevent the cancer from coming back.

Camperdown, New South Wales
NCT06908070Recruiting· Phase 4
Chemoradiation, surgery, then durvalumab for stage 3 lung cancer

This trial tests if giving the immunotherapy drug durvalumab after chemoradiation and surgery helps people with stage 3 non-small cell lung cancer. You will receive standard chemoradiation, then have surgery, and then get durvalumab to see if it lowers the chance of the cancer coming back.

Amsterdam
NCT05696782Recruiting· Phase 2
Durvalumab after chemoradiation for stage III lung cancer

This trial tests giving durvalumab (an immune therapy) soon after standard chemotherapy and radiation for stage II–III non-small cell lung cancer that cannot be removed by surgery. The goal is to see if this “quick start” approach improves outcomes compared with waiting longer to begin durvalumab.

Winston-Salem, North Carolina
NCT05742607Recruiting· Phase 2
Durvalumab plus IPH5201 before lung surgery for early cancer

This phase 2 study tests durvalumab plus IPH5201 given before surgery to improve outcomes for people with resectable non-small cell lung cancer. It aims to shrink or control the cancer and make surgery more effective, using information about specific tumor markers like PD-L1.

St. Petersburg, Florida
NCT04892953Recruiting· Phase 2
Durvalumab plus focused radiation for progressing stage III lung cancer

This trial studies adding focused radiation to some cancer spots in people with stage III non-small cell lung cancer (NSCLC) whose cancer did not fully stop after standard chemoradiation and durvalumab. The goal is to control a small number of growing spots (or more than a few) and improve outcomes after durvalumab.

Houston, Texas

Hear when a new Potentially Resectable Stage II/IIIa NSCLC trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.