Clin2
NCT03758989Possibly a fitRecruiting

PET-guided treatment and monitoring for limited-stage lymphoma

DLBCL

Treatments studied

Part of Blood & lymphatic, Cancer clinical trials.

This Phase 2 study tests a treatment approach guided by PET scans, plus non-invasive monitoring, for adults with limited-stage diffuse large B-cell lymphoma (a type of lymphoma). It may help by tailoring therapy based on scan and other follow-up information, aiming for better outcomes with fewer invasive steps.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
40 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older
  • You have not had treatment yet for limited-stage non-bulky diffuse large B-cell lymphoma (DLBCL), based on standard staging scans and bone marrow biopsy results
  • Your cancer shows up on an FDG-PET scan (a special PET scan that highlights active disease)
  • You can provide tumor tissue from a biopsy (archived tissue or a fresh/frozen sample)
  • Your blood counts, heart, kidneys, and liver tests meet study limits
  • You do not have “bulky” tumors larger than 10 cm in any one direction

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07070648Recruiting
Predicting DLBCL treatment response with ctDNA and PET scans

This trial uses a blood test (ctDNA) and PET scans to predict how well standard first-line treatment works for diffuse large B-cell lymphoma (DLBCL). It aims to find out if these tests can guide better care.

Shanghai, Shanghai Municipality
NCT07594899Not yet recruiting· Phase 2
AI-guided treatment for newly diagnosed large B-cell lymphoma

This study tests whether a computer-guided treatment plan can work as well as or better than the standard chemo-immunotherapy for large B-cell lymphoma. It uses a special test after the first cycle to decide who needs a more aggressive approach.

Shanghai, Shanghai Municipality
NCT06693830Recruiting
Blood test guided treatment for newly diagnosed DLBCL

This trial studies whether using a blood test (ctDNA) can help guide treatment decisions for people with newly diagnosed diffuse large B-cell lymphoma. It tests standard chemotherapy regimens (R-CHOP or R-pola-CHP) and aims to improve outcomes by monitoring tumor DNA in the blood.

New York, New York
NCT07517705Not yet recruiting· Phase 2
Low-dose radiation guided by MRD during first treatment for large B-cell lymphoma

This study tests whether adding low-dose radiation to standard chemoimmunotherapy can improve outcomes for people with newly diagnosed large B-cell lymphoma, using a personalized blood test to guide who gets radiation. It may help reduce the risk of the lymphoma returning by targeting sites still showing signs of disease.

Omaha, Nebraska
NCT07714421Not yet recruiting· Phase 1
Combination treatment for older adults with large B cell lymphoma

This trial tests a new combination of drugs for people with a type of lymphoma called diffuse large B cell lymphoma, especially if you are older or not healthy enough for standard full-dose chemotherapy. The treatment includes two immunotherapy drugs (epcoritamab and polatuzumab) plus a reduced-intensity chemotherapy regimen (mini-CHP). The goal is to see if this combination is safe and effective for people who may not tolerate stronger treatments.

Los Angeles, California
NCT07514715Not yet recruiting
Monitoring lymphoma treatment with pet scans and blood tests

This study tests whether using PET scans and a simple blood test (called liquid biopsy) can quickly and accurately monitor how well your lymphoma is responding to standard first-line treatment. The goal is to see if these real-time monitoring tools can improve care for aggressive B-cell lymphomas.

Amiens

Hear when a new DLBCL trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.