Fecal transplant to treat cancer immunotherapy bowel side effects
Treatments studied
Part of Cancer, Digestive system, Kidney & urinary, Lungs & breathing, Women’s health & pregnancy clinical trials.
This early-phase study tests whether changing your gut bacteria with a fecal transplant can improve diarrhea or colitis caused by cancer immunotherapy. It may help people whose symptoms have not fully settled with standard treatments like steroids and other immune-blocking medicines.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have cancer such as melanoma, non-small cell lung cancer, or certain urinary/gyn cancers, or you fit any cancer type in another part of the study
- You are currently (or were recently) taking an immunotherapy medicine called an immune checkpoint inhibitor (ICPI)
- You have had significant immunotherapy-related diarrhea and/or colitis (grade 2 or higher), treated with standard immune-suppressing medicines
- Your diarrhea/colitis must be timed around the transplant (generally within 45 days before the fecal transplant)
- Infections in the stool must be ruled out before starting the transplant (or your doctor has cleared you if infection risk is known)
- You must be at least 18 years old and able to understand and sign consent and complete questionnaires
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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