Genetic study for inherited aortic disease
Part of Heart & circulation clinical trials.
This trial is for people with inherited (family-run) aortic enlargement or aneurysm caused by a specific DNA gene change. It uses genetic information to guide more precise care, which may help tailor monitoring and treatment for you and your family.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You (or a close family member) have a confirmed gene result linked to heritable thoracic aortic disease
- The gene result is pathogenic, likely pathogenic, or a variant of unknown significance (VUS)
- Your gene test must involve at least one of these genes: TGFBR1, TGFBR2, SMAD3, TGFB2, TGFB3, ACTA2, MYH11, MYLK, PRKG1, MAT2A, MFAP5, LOX, COL3A1, FOXE3, or FBN1
- You can give informed consent (or a legal guardian can, if needed)
- You should NOT be joining if your genetic test has no confirmed causative gene change for this condition
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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