Clin2
NCT04008563Possibly a fitRecruiting

Weight-loss surgery to protect fertility in early womb cancer

Endometrial CancerAtypical HyperplasiaBariatric Surgery Candidate

Part of Cancer, Women’s health & pregnancy clinical trials.

This study tests whether bariatric (weight-loss) surgery can help treat certain early, low-grade womb changes while preserving fertility. It’s mainly for people with a higher BMI who want to have children and have an early stage diagnosis confirmed by scans.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
36 people
Ages
18 years to 41 years
Study type
Interventional

Who can take part

  • BMI is 35 or higher
  • You have been diagnosed with either grade 1 endometrial cancer or complex atypical hyperplasia
  • Your scans show it is confined to the uterus (stage 1) with no spread
  • You want fertility preservation (future pregnancy)
  • You must be able to safely get a progestin IUD and also safely have a sleeve gastrectomy
  • You are not pregnant and you can fully understand and consent to the study

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07462663Not yet recruiting· Phase 4
Pre-surgery weight-loss program for early endometrial cancer

This study compares two approaches for women with obesity and early-stage endometrial cancer: having surgery right away versus going through a special weight-loss and health-optimization program before surgery. The goal is to see if preparing the body before surgery improves outcomes.

NCT07714070Not yet recruiting· Phase 2
Orlistat plus progestin for fertility-sparing treatment of early endometrial cancer or atypical hyperplasia

This trial tests whether adding the weight-loss drug orlistat to standard hormone therapy can help shrink early-stage endometrial cancer or precancerous changes, so you can avoid having your uterus removed and still try for a baby later.

Beijing, Beijing Municipality
NCT07397624Recruiting
Stomach stitching for weight loss in endometrial cancer patients

This study tests a new weight-loss procedure called Endoscopic Suture Gastroplasty (ESG) for women with endometrial (uterine) cancer who are obese. The procedure uses a special camera and stitches to make the stomach smaller, helping you lose weight before your cancer surgery.

Aviano, Pordenone
NCT07605247Not yet recruiting· Phase 2
Medicine for weight loss to treat early endometrial cancer

This study tests whether the medicine tirzepatide, which is used for weight loss, can help women with early-stage endometrial cancer or a pre-cancerous condition avoid or delay surgery. It combines taking tizepatide with a hormonal intrauterine device (Mirena) to try to shrink or stop the cancer from growing.

NCT05974995Recruiting
Robotic or standard surgery for early uterine cancer in obesity

This trial compares robotic-assisted surgery versus standard laparoscopic surgery for people with early-stage uterine (endometrial) cancer and a BMI of 30 or higher. The goal is to see which approach is safer and works better for this group.

Rome
NCT06901778Not yet recruiting
Weight management app for fertility preservation in endometrial cancer

This study tests whether a mobile app can help women with early-stage endometrial cancer who are overweight or obese manage their weight while they undergo fertility-sparing treatment. Losing weight may improve treatment outcomes and overall health.

Beijing

Hear when a new Endometrial Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.