Avoid extra lymph-node radiation for certain node-positive breast cancers
Part of Cancer, Skin clinical trials.
This trial tests a way to decide whether you can safely receive less radiation to lymph nodes after surgery for breast cancer that has spread to nearby nodes. If you qualify as “low risk,” the goal is to reduce radiation exposure while keeping cancer control safe.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 to 70 years old, and generally able to do most daily activities (ECOG 0–2).
- Your surgery pathology confirms invasive breast cancer and specific types of lymph-node involvement (small “micrometastasis” or limited node spread).
- You had breast-conserving surgery or a full breast removal with reconstruction (not just total mastectomy with only a sentinel node biopsy).
- You completed at least 4 rounds of standard chemotherapy after surgery (or may skip chemo only for some hormone-receptor/low-risk test results).
- There’s no sign of spread to distant organs on scans done within 3 months before radiation, and no other breast cancer on the opposite side in the prior 12 months.
- Your medical records must allow the lab test called “RecurIndex,” using your stored tumor tissue.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether some women with low-risk breast cancer that has spread to a few lymph nodes can safely skip radiation therapy after surgery. It aims to reduce side effects while keeping the cancer from coming back.
This trial compares the benefits and risks of adding radiation therapy to the lymph nodes near the breast after surgery for people with breast cancer that has spread to a small number of lymph nodes. It may help prevent the cancer from coming back in those lymph nodes.
This trial is testing whether radiation therapy to just the breast (not the lymph nodes) is safe and effective for women with early-stage, low-risk breast cancer. It aims to see if omitting the sentinel node biopsy is acceptable when the cancer has not spread to the lymph nodes.
This trial looks at whether adding targeted radiation to lymph nodes after breast surgery can lower the chance of breast cancer coming back in people with higher-risk, node-negative disease. If you qualify, you may get a planned radiation approach designed for prevention, not treatment of spread.
This trial tests shorter radiation schedules for people with breast cancer that has spread to lymph nodes or is high-risk. It aims to find a shorter course of radiation that is just as effective after surgery.
This trial is testing whether it's safe to reduce the amount of radiation therapy to the lymph nodes for breast cancer patients whose lymph nodes become cancer-free after neoadjuvant (pre-surgery) treatment. The goal is to see if less radiation is just as effective and causes fewer side effects.
Hear when a new Breast cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.