Test drug safety in adults with multiple system atrophy
Part of Brain & nervous system clinical trials.
This Phase 1 study checks how safe a drug called ION464 is, how the body handles it, and how much of the drug reaches the bloodstream in adults with multiple system atrophy (MSA). It may help researchers find a dosing approach for future treatments for MSA.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your scan (DaTscan SPECT) shows Parkinson-type nerve loss in the brain’s striatum
- You have a diagnosis of multiple system atrophy (either parkinson-type or cerebellar-type)
- You can walk by yourself for at least 10 meters (about 30 feet)
- Your thinking/memory test (MoCA) must be 25 or higher
- No known genetic cause of Parkinsonism/ataxia in your family, and you don’t have that known cause
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study collects data from people with Parkinson's disease or multiple system atrophy (MSA) to better understand these conditions. You will have blood, saliva, optional spinal fluid tests, and brain scans (MRI, PET/SPECT).
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