CAR T-cell treatment for hard-to-treat B-cell lymphomas
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial studies a type of lab-made immune cell therapy (CAR T) using cells called CAR-20/19-T. It is for adults with relapsed or refractory B-cell cancers, aiming to reduce or eliminate lymphoma in people whose disease has come back or not responded to standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be age 18–80, and have a B-cell non-Hodgkin lymphoma that has come back or is resistant to treatment.
- Have enough immune cells and organ function on blood tests (including liver, kidney, and specific blood counts).
- Have measurable disease on scans or biopsy recently (within 4 weeks of signing consent).
- Be well enough to tolerate treatment (Karnofsky score 70 or higher).
- Usually have no lymphoma in the brain/spinal fluid; special brain-spinal fluid rules apply for people with prior or suspected CNS involvement.
- Be able to sign consent, follow study rules, and use birth control during the study if pregnancy is possible.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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