Botox shot to help prevent a pancreas leak after distal surgery
Treatments studied
Part of Digestive system clinical trials.
This trial studies whether injecting a Botox-like medicine into the pancreatic drainage area can help prevent a post-surgery pancreas fistula (a persistent leak). It’s for adults having a planned distal pancreatectomy, and it may help reduce complications after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and scheduled for a distal pancreatectomy (open or laparoscopic), with or without spleen removal
- You are not pregnant or breastfeeding
- You do not have myasthenia gravis or Eaton-Lambert syndrome
- Your general health is not too high-risk (ASA score must be 3 or lower)
- Your imaging does not suggest pancreas divisum or calcified chronic pancreatitis
- You can give informed consent and are able to follow the study timing
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests injecting a medical glue into the pancreas during a Whipple procedure to see if it can prevent leaks. It may help people with a soft pancreas and small pancreatic duct.
This Phase 3 trial studies a pancreatic surgery approach (pylorus-preserving Whipple or similar) and, in some cases, moving your insulin-making cells into your body to help prevent a dangerous post-surgery leak from the pancreas. It may help people who are considered high risk for this complication based on pancreas texture and duct size.
This trial tests a new method using a surgical glue called N-butyl-2-cyanoacrylate to seal the pancreas after a Whipple procedure. It may help prevent leaks and improve recovery for patients with a soft pancreas and small pancreatic duct.
This Phase 1/2 study tests whether adding an islet (insulin-producing cell) transplant at the time of pancreatic-region surgery is safe and helps prevent a serious surgical complication called a postoperative fistula. It is for people whose surgery is considered high risk for developing that complication.
This trial tests if a short course of radiation before surgery can lower the risk of a pancreatic leak (a common complication). It is for people who are overweight, older than 45, and have a small pancreatic duct.
This study tests if octreotide microspheres (a slow-release drug) can prevent pancreatic fistula—a common complication after surgery to remove the tail of the pancreas. The goal is to help patients heal with fewer complications.
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