Surgery choice and insulin islet transplant to prevent leaks
Part of Cancer, Digestive system, Hormones & metabolism clinical trials.
This Phase 3 trial studies a pancreatic surgery approach (pylorus-preserving Whipple or similar) and, in some cases, moving your insulin-making cells into your body to help prevent a dangerous post-surgery leak from the pancreas. It may help people who are considered high risk for this complication based on pancreas texture and duct size.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have (or are suspected to have) periampullary cancer and you are scheduled for Whipple or pylorus-preserving Whipple surgery
- You are high risk for a post-surgery pancreatic leak: your pancreas is “soft” and your pancreatic duct is smaller than 3 mm before/ during surgery
- No other procedure is planned at the same time as your Whipple/PPPD surgery
- You do not have certain infections or immune concerns: HIV, hepatitis C antibodies, or active hepatitis B markers
- You are not currently enrolled in another clinical trial within the past 4 weeks and you can follow the study plan
- You are not pregnant or breastfeeding (and if you can get pregnant, you must meet specific contraception/menopause requirements)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial looks at factors that can predict a serious complication called a pancreatic fistula (a leak from the pancreas) after a Whipple procedure. The goal is to help doctors better understand and manage this risk.
This study tests injecting a medical glue into the pancreas during a Whipple procedure to see if it can prevent leaks. It may help people with a soft pancreas and small pancreatic duct.
This trial tests a new method using a surgical glue called N-butyl-2-cyanoacrylate to seal the pancreas after a Whipple procedure. It may help prevent leaks and improve recovery for patients with a soft pancreas and small pancreatic duct.
This trial studies whether injecting a Botox-like medicine into the pancreatic drainage area can help prevent a post-surgery pancreas fistula (a persistent leak). It’s for adults having a planned distal pancreatectomy, and it may help reduce complications after surgery.
This Phase 1/2 study tests whether adding an islet (insulin-producing cell) transplant at the time of pancreatic-region surgery is safe and helps prevent a serious surgical complication called a postoperative fistula. It is for people whose surgery is considered high risk for developing that complication.
This trial removes the whole pancreas in people with certain pancreatic tumors and then transplants the patient's own insulin-making cells (islets) into the liver. The goal is to prevent or reduce diabetes after surgery.
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