Natural killer cell injections in the brain tumor area
Treatments studied
Part of Cancer clinical trials.
This early-phase trial tests injections of lab-grown immune cells directly into (or near) a brain tumor. It aims to see if the treatment is safe and can help control recurrent, progressive, or resistant CNS tumors.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed malignant brain/spinal cord tumor that is recurrent, progressing, or not responding to treatment
- You cannot have diffuse midline glioma or diffuse intrinsic pontine glioma (DMG/DIPG)
- Your care team must be able to place an Ommaya reservoir or a programmable VP shunt for tumor-area delivery
- Your brain surgery cavity must be large enough (at least 2 cm by 2 cm in two dimensions on imaging) if using the tumor-area infusion plan
- You must be well enough to participate (Lansky/Karnofsky performance score at least 50) and have acceptable liver, kidney, bone-marrow, and clotting blood tests
- You must have had enough time since prior treatments and be off certain medicines (including specific immune-suppressing meds, growth factors, and unstable steroid dosing)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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