Clinical trials
High Grade Glioma clinical trials
Below are recruiting high grade glioma clinical trials, each written for real people, not researchers. We’re tracking 117 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04316039RecruitingPhase 2/Phase 3
Radiation alone or with temozolomide for brain tumor after surgery
This trial compares standard radiation therapy versus radiation plus a chemotherapy medicine called temozolomide in people with a newly diagnosed low-grade (WHO grade II) brain glioma after surgery. It’s designed to see if adding temozolomide improves outcomes while managing side effects.
Chengdu, SichuanAges 18–70 - NCT06118723Recruiting
Supramaximal vs maximal surgery for brain tumors
This trial compares removing as much tumor as safely possible (supramaximal resection) with standard maximal resection in people with high-grade glioma (an aggressive brain tumor). The goal is to see if more extensive removal improves survival and quality of life.
San Francisco, CaliforniaAges 18–90 - NCT06215495Recruiting
New radiation target method for high-grade glioma
This study is testing a new way to target radiation for people with high-grade gliomas (aggressive brain tumors). The goal is to see if a more precise treatment plan can improve outcomes while keeping side effects low.
GuangzhouAges 18–65 - NCT06330337RecruitingPhase 3
Electroacupuncture plus paclitaxel for recurrent high-grade glioma
This trial tests whether adding electroacupuncture (a type of acupuncture with mild electric pulses) to the chemotherapy drug paclitaxel can help people with recurrent high-grade glioma. The goal is to see if the combination works better than paclitaxel alone.
ZhejiangAges 18–70 - NCT07832734Recruiting
Brain tumor tissue analysis for glioma diagnosis
This study looks at the chemicals and genes in brain tumors called gliomas to find better ways to diagnose and treat them. People with a brain mass that needs surgery may be able to join.
Milan, LombardyAges 18 years+ - NCT07710690RecruitingPhase 1
Study of NRG-103 injection for recurrent high-grade glioma
This trial tests a new injection called NRG-103 for people whose high-grade glioma (a fast-growing brain tumor) has come back after standard treatments. The goal is to see if it's safe and if it might help shrink the tumor.
ShanghaiAges 18 years+ - NCT07710040RecruitingPhase 1
Proton radiation before surgery for high-grade brain tumors
This trial tests proton radiation therapy given before surgery for people with a single, high-grade brain tumor. The goal is to see if pre-surgery radiation helps with treatment outcomes.
Obninsk, Kaluga OblastAges 18 years+ - NCT07664176RecruitingPhase 1
Focused ultrasound plus nivolumab for children with brain tumors
This trial tests if combining focused ultrasound (which opens the blood-brain barrier) with the immunotherapy drug nivolumab can treat relapsed or progressive brainstem gliomas and other high-grade brain tumors in children and young adults.
Washington D.C., District of ColumbiaAges 3–25 - NCT07655869RecruitingEarly Phase 1
Lu177-DOTA-EB-RGD2 therapy for returning high-grade glioma
This trial tests a radioactive drug that targets a protein on tumor blood vessels to treat glioblastoma that has come back after standard treatment. It may help shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07649070RecruitingPhase 2
Virus therapy and low-dose radiation for children with aggressive brain cancer
This trial tests whether a special herpes virus (G207) combined with low-dose radiation can help children with high-grade brain tumors (gliomas). The virus is injected into the tumor to attack the cancer cells while radiation helps boost the effect.
Houston, TexasAges 3–21 - NCT06161610Recruiting
Laser treatment for returning high-grade glioma
This study tests a laser ablation treatment for people whose high-grade glioma (a fast-growing brain tumor) has come back after standard therapy. The goal is to see if this minimally invasive laser procedure can help control the tumor.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06172595RecruitingPhase 2
PET scan to tell tumor growth from treatment effects in brain cancer
This trial tests whether a special PET scan can tell the difference between actual tumor growth and treatment-related changes in people with aggressive brain cancer (high-grade glioma). If you have had radiation and an MRI shows a growing lesion, this study may help clarify the cause.
SingaporeAges 21 years+ - NCT06736470Recruiting
Fluorescence measurement of brain tumor suction samples
This trial is testing a new way to measure fluorescence in fluid suctioned from the brain during glioma surgery. It may help surgeons better identify tumor tissue.
Kuopio, KuopioAges 18 years+ - NCT07567196Recruiting
PET imaging to guide surgery for aggressive brain tumors
This trial tests whether using a special PET scan (a type of imaging that shows tumor activity) during brain tumor surgery helps doctors remove more of the tumor safely. You would have a high-grade glioma (an aggressive brain cancer) and be scheduled for surgery.
Torino, TurinAges 18 years+ - NCT07551336RecruitingPhase 1
CAR-NK cells for recurrent glioblastoma and high-grade brain tumors
This trial tests a new type of immune cell therapy called CAR-NK cells to treat glioblastoma or high-grade glioma that has come back or gotten worse after standard treatment. The cells are engineered to recognize and attack tumor cells in the brain.
Shenzhen, GuangdongAges 18–75 - NCT07541781RecruitingPhase 1
Sitagliptin for recurrent grade 4 glioma
This trial tests whether the diabetes drug sitagliptin (Januvia) can help slow or shrink a recurrent grade 4 glioma (a type of brain tumor). It's for people whose tumor has come back after standard treatment and who have not used sitagliptin or Avastin before.
Iowa City, IowaAges 18 years+ - NCT07480941RecruitingPhase 1
CAR-NK cell therapy for recurrent glioblastoma
This trial tests a new treatment using engineered immune cells (CAR-NK cells) that target two markers found on glioblastoma tumors. The treatment is given directly into the brain to fight tumors that have come back after standard therapy.
Shenzhen, GuangdongAges 18–75 - NCT07459101Recruiting
MR-guided radiation therapy for high-grade brain tumors
This study tests a new way to deliver radiation therapy for a type of aggressive brain tumor called glioblastoma or grade 4 astrocytoma. Patients get MRI scans during each treatment so the radiation beam can be adjusted precisely, aiming to improve outcomes.
Toronto, OntarioAges 18 years+ - NCT07439172RecruitingPhase 2
Chemotherapy before radiation for newly diagnosed brain tumors
This trial tests giving a chemotherapy drug called temozolomide before radiation therapy to people with a newly diagnosed high-grade brain tumor. The goal is to see if this approach can help control the tumor better.
Camden, New JerseyAges 18–80 - NCT07424092RecruitingPhase 2
Virus injection for children with recurrent brain tumors
This trial is testing a virus called DNX-2401, which is injected directly into the tumor, for children and young adults with high-grade brain tumors that have come back or are hard to treat. The goal is to see if this virus can shrink or control the tumor.
UtrechtAges 1–25 - NCT07416188RecruitingPhase 1/Phase 2
LMP744 drug for returning glioblastoma
This trial tests an experimental drug called LMP744 for people whose glioblastoma has come back. It aims to see if the drug can slow or stop tumor growth by targeting specific proteins in cancer cells.
Bethesda, MarylandAges 18–99 - NCT06831773Recruiting
Carbon ion radiation for high-grade brain tumors
This trial tests a precise type of radiation called carbon ion radiotherapy for people with aggressive brain tumors (high-grade gliomas). It aims to see if this treatment is safe and effective for patients who have not had radiation to the head before.
Wuwei, GansuAges 14–80 - NCT07346144RecruitingPhase 1/Phase 2
Gene therapy study for high-grade glioma
This trial tests a new gene therapy given directly into the brain tumor. It's for people with high-grade glioma, either newly diagnosed or after one recurrence, to see if it can help control the tumor.
Columbus, OhioAges 18–70 - NCT06660056RecruitingPhase 1
GC001 injection for returning or growing high-grade brain tumors
This trial tests a new drug, GC001, injected directly into the tumor in people with high-grade gliomas (WHO grade 3 or 4) that have come back or are growing. It may be an option if standard treatments have stopped working.
Beijing, Beijing MunicipalityAges 18 years+
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High Grade Glioma trials by city
Studies with a site in or near these metro areas.
High Grade Glioma trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for high grade glioma?
- Yes. Clin2 currently lists 117 recruiting high grade glioma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high grade glioma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high grade glioma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.