Cryoablation plus pembrolizumab and chemotherapy for lung cancer spread
Treatments studied
Part of Cancer clinical trials.
This trial studies whether freezing a small number of lung cancer spots (cryoablation) alongside standard immunotherapy (pembrolizumab) and chemotherapy can improve outcomes in people with metastatic lung adenocarcinoma. It’s meant for people who have measurable tumors that can be safely targeted with the freezing treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have confirmed lung adenocarcinoma (not squamous) based on lab tests on tissue or cells.
- Your cancer has spread to other parts of the body (metastatic disease).
- You will be receiving pembrolizumab with pemetrexed-carboplatin as the study treatment plan.
- You have at least two measurable tumor spots on CT or MRI, including one that can be treated with cryoablation (freezing).
- You are 18 or older, and your overall functioning is not too limited (performance status 0–2).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of an immunotherapy drug (sintilimab), chemotherapy, and a procedure called cryoablation (freezing the tumor) for people with a type of lung cancer called non-small cell lung cancer that has spread or come back. The goal is to see if this combination is safe and effective.
This trial tests a combination of a drug that helps your immune system fight cancer (serplulimab) and a procedure that freezes and destroys cancer cells (cryoablation) for people with early-stage non-small cell lung cancer who cannot or choose not to have surgery or radiation. The goal is to see if this combination is safe and effective.
This trial tests a treatment for early-stage lung cancer (stage I-IIA) that uses extreme cold to freeze and destroy the tumor, called cryoablation. Some patients will also receive an immunotherapy drug called serplulimab, which helps the immune system fight the cancer, to see if adding it improves outcomes.
This trial tests whether combining pembrolizumab (an immune treatment) with a lung ablation procedure can be safer and more effective for advanced non-small cell lung cancer after standard first treatment fails or the cancer comes back. It may help shrink tumors and improve control of the disease.
This trial tests freezing tumors (cryoablation) combined with two drugs (Karelizumab and Apatinib) for people who have several small lung cancer spots in their lungs but no spread to lymph nodes. The goal is to see if this combination is safe and helps shrink or control the tumors.
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