Freezing lung tumors with or without immunotherapy
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial tests a treatment for early-stage lung cancer (stage I-IIA) that uses extreme cold to freeze and destroy the tumor, called cryoablation. Some patients will also receive an immunotherapy drug called serplulimab, which helps the immune system fight the cancer, to see if adding it improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have non-small cell lung cancer that is stage I or IIA (tumor 5 cm or smaller, not spread to lymph nodes).
- Your cancer does not have certain genetic changes (like EGFR or ALK) that would call for different treatments.
- You are 18 or older and are healthy enough to get around and take care of yourself (performance status 0-2).
- You are not a good candidate for surgery or radiation, or you have chosen not to have them.
- You have not had immunotherapy (PD-1, PD-L1, or CTLA-4 inhibitors) before.
- You agree to receive cryoablation (freezing the tumor) with or without the study drug serplulimab, and you are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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