Pre-surgery chemotherapy choices for stage III stomach cancer
Part of Cancer, Digestive system clinical trials.
This study compares two chemotherapy plans given before surgery for stage III stomach cancer (or the area where the esophagus meets the stomach). The goal is to see which approach works better to control the cancer and help people get the best surgical outcome.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have stomach or esophago-gastric junction adenocarcinoma confirmed by pathology (biopsy).
- Your cancer is stage III based on scans and exams (cTNM stage III).
- Your overall functioning is fairly good (ECOG 0 to 2—able to be up for most of the day).
- You can safely handle both chemotherapy and major surgery (kidney, liver, blood counts, and lung function are adequate).
- You have not had chemotherapy or radiation before, and you are not in another study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks for ways to predict whether neoadjuvant chemotherapy (chemo given before surgery) will work well in people with locally advanced stomach cancer. It may help doctors choose the best treatment plan sooner based on your test results.
This trial compares giving chemotherapy before surgery versus going straight to surgery in older adults with stage III stomach (or where the esophagus meets the stomach) cancer. It’s meant to see which approach works better to control the cancer and improve outcomes.
This trial tests a combination of chemotherapy drugs given before surgery for locally advanced stomach or gastroesophageal junction cancer. It aims to see if this approach helps shrink the tumor and improve outcomes.
This study tests combining an immunotherapy drug (PD-1 inhibitor) and a medication to boost your immune system (thymalfasin) with standard chemotherapy and radiation before surgery for stage III cancer where the stomach meets the esophagus. The goal is to see if this approach can shrink the tumor and improve outcomes.
This trial is for people who have already had chemotherapy and surgery for stomach cancer. It compares different follow-up approaches to see if skipping more chemo after surgery is safe and effective.
This trial studies which surgical approach (removing lymph nodes in a more limited vs more extensive way) works best for gastric cancer after you’ve already started chemotherapy before surgery. It’s aimed at improving cancer control while keeping the operation as safe as possible.
Hear when a new Gastric Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.