Buspirone and melatonin for depression after a brain injury
Treatments studied
Part of Brain & nervous system, Injuries & trauma clinical trials.
This trial studies whether the medicines buspirone and melatonin can reduce depression symptoms in people who had a mild or moderate traumatic brain injury (TBI) at least 3 months ago. It may help if you have ongoing depression after TBI and can safely take study medications and attend regular visits, including MRI scans.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had a non-penetrating mild or moderate TBI at least 3 months ago
- You are 18 to 64 years old
- You have a current diagnosis of major depression, and your depression scores are high enough
- Your injury severity fits one of these: early coma score was 9–15, or you lost consciousness 1 minute to 24 hours, or memory gap was under 7 days
- You can speak English and attend regular study appointments
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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