Valve replacement for severe mitral valve disease in high-risk adults
Part of Heart & circulation clinical trials.
This trial tests a less-invasive way to treat severe mitral valve problems using a transcatheter valve. It may help people who are too high-risk for standard open-heart mitral surgery by improving symptoms and heart function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have severe mitral valve disease causing symptoms (either severe narrowing, moderate-to-severe leaking, or a mix).
- Your symptoms are at least moderate (NYHA Class II or higher).
- A heart team thinks placing a valve is likely to help you, and open mitral surgery is high-risk or not safe for you.
- You agree to the procedure, sign consent, and return for follow-up visits every year for up to 5 years.
- You cannot be a good surgical candidate for this “less-invasive valve” study option.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new device that replaces a leaking mitral valve without open-heart surgery. It may help people who have severe mitral valve leakage but cannot safely have standard surgery or some other less invasive valve repairs.
This trial studies a catheter-based procedure to replace the mitral valve in people with severe (or specific moderate) mitral valve leakage that causes symptoms. It may help by reducing leaking and related symptoms when standard surgery or less invasive fixes aren’t suitable for you.
This study tests a new catheter-based system to treat severe mitral valve leaking when open-heart surgery is considered high risk. It may help improve blood flow and symptoms by repairing the valve without open surgery, using ultrasound guidance and follow-up visits to track safety and results.
This study looks at how safe and effective a specific catheter procedure is for people with moderate-to-severe mitral valve leakage. It may help those who are considered high risk for traditional open-heart surgery.
This study looks at how long a new mitral valve treatment/device can stay working in people with moderate-to-severe or severe mitral valve leak. It may help avoid or delay surgery for people considered higher risk for mitral valve repair.
This trial tests a new device called the Capstan system to fix a leaky mitral valve (mitral regurgitation) without open-heart surgery. It may help people whose valve leak is moderate to severe and still have symptoms despite medicines.
Hear when a new Mitral Annular Calcification trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.