Clin2
NCT04541368Worth exploringNot yet recruiting

CS1-targeted CAR-T cells for multiple myeloma after BCMA therapy

Relapse Multiple Myeloma

Part of Blood & lymphatic, Cancer, Heart & circulation, Immune system & allergy clinical trials.

This trial tests a new type of immune cell therapy (CAR-T) that targets a protein called CS1 on myeloma cells. It is for people whose myeloma has come back after a previous BCMA CAR-T treatment.

Summary written for real people, not researchers, by Clin2.

Phase
Early Phase 1
Enrollment
50 people
Ages
30 years to 75 years
Study type
Interventional

Who can take part

  • You have been diagnosed with multiple myeloma (a type of blood cancer).
  • Your cancer either came back after BCMA CAR-T therapy, or your cancer cells have CS1 but not BCMA.
  • You are between 30 and 75 years old.
  • Your doctor expects you to live at least 12 more weeks (about 3 months).
  • You have not had other CAR-T or genetically modified T cell treatments before.
  • You do not have serious heart, liver, kidney, or active infection problems.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04670055Not yet recruiting· Early Phase 1
Car-t cell therapy for relapsed or refractory multiple myeloma

This trial tests a new type of cell therapy (CAR-T cells) that is designed to find and destroy myeloma cells that have a protein called BCMA. It is for people whose multiple myeloma has come back or hasn't responded to other treatments.

Hangzhou, Zhejiang
NCT05243212Recruiting· Phase 1/Phase 2
CAR-T cell therapy for multiple myeloma

This Phase 1/2 study tests a personalized CAR-T cell treatment that targets a protein called BCMA on myeloma cells. It’s designed for people with multiple myeloma who have already tried several other treatments and still have measurable disease.

Ramat Gan
NCT05594797Recruiting· Phase 2
BCMA CAR-T for multiple myeloma that came back or stopped working

This trial tests a one-time BCMA CAR-T cell treatment for people with multiple myeloma that relapsed or did not respond well to prior treatments. It may help by training your own immune cells to recognize and attack myeloma cells.

Shanghai, Shanghai Municipality
NCT07248176Recruiting
Universal CAR-T therapy for multiple myeloma

This trial tests a universal CAR-T cell therapy (made from donated cells) for multiple myeloma that has come back after at least two prior treatments. It may be an option if your cancer cells have a specific marker called BCMA and you have not had certain prior therapies.

Shanghai
NCT07003555Recruiting· Phase 1
Dual-target CAR-T therapy for multiple myeloma with extramedullary disease

This trial tests a new CAR-T cell treatment that targets two proteins (BCMA and CD19) on myeloma cells. It is for patients whose multiple myeloma has come back or stopped responding to other treatments and has spread to tissues outside the bone marrow.

Shanghai
NCT06581640Recruiting· Phase 2
BCMA-targeting CAR-T cells for relapsed/refractory myeloma

This trial tests a new type of immune cell therapy (CAR-T cells) that targets a protein called BCMA on multiple myeloma cells. It is for people whose myeloma has come back or has not responded to other treatments.

Xiamen, Fujian

Hear when a new Relapse Multiple Myeloma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.