Clin2
NCT04772287Possibly a fitNot yet recruiting

Study drug after lung surgery for EGFR/ALK-negative lung cancer

Non Small Cell Lung Cancer

Treatments studied

Part of Cancer, Lungs & breathing clinical trials.

This phase 3 trial tests adding toripalimab (an immunotherapy) to standard chemotherapy after surgery for certain stage II to IIIB (N2) lung cancers. It aims to lower the chance the cancer comes back by treating tiny remaining cancer cells and supporting your immune system.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
341 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • Be an adult (age 18 or older) and agree to sign informed consent.
  • Have non-small cell lung cancer (NSCLC) that was completely removed with surgery (no remaining tumor).
  • Your brain scan (CT or MRI) before surgery or before randomization shows no brain metastases.
  • Your tumor should be EGFR/ALK mutation negative (not EGFR-mutant and not ALK-rearranged).
  • After surgery, your cancer stage must be stage II, IIIA, or IIIB (N2), and you must have recovered well from the operation.
  • Your overall health and blood tests must be within allowed ranges (including certain liver, kidney, and blood counts).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04875585Recruiting· Phase 2
Neoadjuvant and post-surgery immunotherapy for operable lung cancer

This trial tests a combination of medicines given before surgery and immunotherapy after surgery for resectable non-small cell lung cancer (NSCLC). It aims to shrink the tumor before the operation and reduce the risk of cancer coming back after surgery.

Innsbruck, Tyrol
NCT07608159Not yet recruiting· Phase 3
Radiation, immunotherapy, and chemotherapy before lung cancer surgery

This trial tests a combination of radiation therapy, an immunotherapy drug called toripalimab, and chemotherapy given before surgery for stage II-III non-small cell lung cancer. The goal is to shrink the tumor before removal and improve survival outcomes.

NCT05800340Recruiting· Phase 2
Immunotherapy before surgery for certain rare lung cancer mutations

This Phase 2 study tests an immunotherapy treatment given before surgery for people with stage IIB to IIIB non-small cell lung cancer (NSCLC) that has specific rare “driver” gene changes. The goal is to shrink the cancer and improve outcomes by treating it earlier with the immune system.

Guanzhou, Guangdong
NCT06467617Recruiting· Phase 2
Immunotherapy and chemo before and after lung cancer surgery

This trial tests a combination of an immunotherapy drug (adebrelimab) plus chemotherapy and another drug (recaticimab) before and after surgery for people with stage II or III lung cancer that can be removed. The goal is to see if this approach helps shrink tumors and improves outcomes.

Beijing, Beijing Municipality
NCT07672223Not yet recruiting· Phase 3
Study of a drug combo after lung cancer surgery

This trial tests a combination of SYS6010 and an immunotherapy drug (anti-PD-(L)-1) given after surgery to prevent non-small cell lung cancer from coming back. It's for people whose cancer was removed but didn't shrink much with prior treatment before surgery.

NCT05962021Not yet recruiting· Phase 2
Immunotherapy before surgery for EGFR-mutated lung cancer

This Phase 2 trial studies giving toripalimab (an immune therapy drug) before lung surgery for EGFR-mutated, operable (resectable) non-squamous non-small cell lung cancer. It aims to see whether shrinking or controlling the cancer before surgery can improve outcomes.

Hear when a new Non Small Cell Lung Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.