Radiation before lung transplant to help stop lung cancer spread
Part of Cancer, Lungs & breathing clinical trials.
This study tests a focused, low-dose type of radiation given before a lung transplant. The goal is to help your immune system recognize and attack cancer cells (called “radiovaccination”) and improve outcomes for people who cannot get curative treatment with surgery or SBRT alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have severe (end-stage) lung disease and a suspected or confirmed stage I lung cancer, and it isn’t treatable with cure-level surgery or SBRT.
- Your cancer must fit one of these patterns: multiple spots in the lungs, or a few isolated metastases in one or both lungs after the main tumor was removed, with no other areas of spread.
- You are eligible for a lung transplant, except that the cancer diagnosis is the main reason you need this study.
- Your scans show no spread to mediastinal lymph nodes (using EBUS) and no distant metastases on PET or brain imaging.
- You must be able to understand the study, read, and sign informed consent.
- You cannot have had prior chest/mediastinal radiation that would block re-irradiation due to overlap with the needed treatment area.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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