Clin2
NCT04908566Possibly a fitRecruiting

PD-1 immunotherapy plus chemotherapy before and after gastric surgery

Locally Advanced Gastric Adenocarcinoma

Part of Cancer, Digestive system clinical trials.

This trial studies whether adding a PD-1 immune therapy to chemotherapy around the time of surgery can improve outcomes for people with locally advanced stomach or stomach–esophagus junction cancer. It aims to better control the cancer before and reduce the chance it comes back after surgery.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
124 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are 18 to 75 years old and can consent to the study
  • Your stomach or stomach–esophagus junction cancer has been newly diagnosed and is planned for surgical removal
  • Your cancer scans show measurable spots that can be tracked (about 1 cm or larger)
  • You are well enough for treatment (KPS score 80–100) and can receive chemotherapy
  • You do not have spread to distant organs or return of cancer

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05505461Not yet recruiting· Phase 2
Immunotherapy plus chemoradiation for stomach cancer before surgery

This trial tests whether giving immunotherapy (a treatment that helps your immune system fight cancer) along with chemotherapy and radiation before surgery can help shrink tumors in people with stomach cancer at the esophagus-stomach junction. The goal is to see if this approach is safe and effective before the main surgery.

Beijing, Beijing Municipality
NCT05960955Recruiting· Phase 2
Testing immunotherapy plus chemo around the time of gastric surgery

This study tests whether adding cadonilimab (and possibly AK117) to chemotherapy can improve outcomes for people with resectable stomach or stomach–esophagus cancer. It aims to see if this combination works better than chemotherapy alone, while still being safe around surgery.

Tianjin
NCT05033392Recruiting· Phase 2
PD-1 therapy plus chemotherapy before stomach cancer surgery

This Phase 2 trial tests whether adding a PD-1 antibody (JS001/toripalimab) to chemotherapy before surgery can improve outcomes for people with locally advanced stomach or gastroesophageal junction adenocarcinoma. It aims to help shrink the tumor and make surgery more effective.

Shenzhen, Guangdong
NCT04997837Recruiting· Phase 3
Adjuvant chemo with or without PD-1 for stomach cancer after surgery

This Phase 3 trial studies whether adding an immune medicine called PD-1 (given as an “inhibitor”) to standard chemotherapy and chemoradiation after stomach/GEJ cancer surgery can lower the risk of cancer coming back. You may qualify if you’ve had surgery removing the tumor and lymph nodes showed higher-risk disease.

Shanghai, Shanghai Municipality
NCT06766578Recruiting· Phase 2
Low-dose radiation plus immunotherapy and chemo before gastric cancer surgery

This trial tests a new combination of low-dose radiation, an immunotherapy drug (tirelizumab), and chemotherapy (SOX) given before surgery for locally advanced gastric or gastroesophageal junction cancer. The goal is to see if this approach can shrink tumors more effectively.

Jinan, Shandong
NCT07263386Recruiting· Phase 2
Immunotherapy plus chemo for PD-L1-positive stomach cancer

This trial tests whether adding the immunotherapy drug sintilimab to standard chemotherapy (SOX) after surgery helps prevent stomach cancer from returning. It’s for people whose tumors have a protein called PD-L1 and who had cancer in at least 7 lymph nodes.

Nanjing, Jiangsu

Hear when a new Locally Advanced Gastric Adenocarcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.