Mesalamine to help prevent colon cancer in Lynch syndrome
Treatments studied
Part of Cancer, Digestive system, Genetic & congenital, Hormones & metabolism clinical trials.
This trial tests whether mesalamine, a medicine used for bowel inflammation, can help prevent colorectal cancer in people with Lynch syndrome who do not currently have cancer. It may help by lowering the chance that new pre-cancer growths form over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have Lynch syndrome with a known inherited gene change in MLH1, MSH2 (including EpCAM), or MSH6
- You are age 30 or older
- Your colon is currently free of cancer; any polyps must be fully removed in an endoscopy before joining
- You have no metastatic (spread) cancer and no past colon cancer at stage 3 or 4
- You can’t take daily aspirin/at least 100 mg or daily NSAID/COX-2 medicine for more than 3 straight months in the last year
- You must have good kidney and liver health (and you can’t be pregnant or breastfeeding)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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