Aspirin or naproxen to prevent cancer in Lynch syndrome
Part of Cancer, Digestive system, Genetic & congenital, Hormones & metabolism clinical trials.
This trial tests whether daily aspirin or naproxen can “intercept” (stop) cancer from starting or coming back in people with Lynch syndrome who are currently cancer-free. Participants are randomly assigned to one of the two drugs, and neither the participant nor the team knows which one you’re taking.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have Lynch syndrome confirmed by genetic testing, or by specific tumor/test findings
- You must be cancer-free or without active/recurrent cancer for at least 6 months
- You must be at least 6 months away from any cancer treatment like surgery, chemo, radiation, or immunotherapy
- You need bowel anatomy that can be checked with colonoscopy or sigmoidoscopy (part of the left colon or rectum must still be there)
- You must agree to stop using aspirin/NSAIDs/COX-inhibitors during the study (with special rules if you take low-dose daily aspirin for heart protection)
- You must be able to do two lower-bowel endoscopy visits with biopsies, about 12 months apart, plus yearly screening for the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study is testing whether a simple blood test can safely replace some of the more invasive procedures used to monitor people with Lynch syndrome, a condition that increases the risk of certain cancers (especially colorectal and uterine). If the blood test works as well, it could mean fewer colonoscopies and other invasive tests for those with Lynch syndrome.
This trial tests whether a personalized vaccine made from your own immune cells can help prevent cancer in people with Lynch syndrome. You must have no history of cancer and be willing to have regular colonoscopies.
This study looks at how the immune system interacts with the gut lining in people with Lynch syndrome and those without. It may help us better understand how Lynch syndrome affects the body.
This study collects blood and stool samples to see how well they can detect colorectal cancer or advanced growths in people with Lynch syndrome (an inherited colon cancer risk) or suspected Lynch syndrome. It may help find cancer or precancer earlier, which can improve next-step decisions.
This trial tests a preventive vaccine made from your own immune cells (dendritic cells) that is designed to teach your body to fight off Lynch syndrome-related cancers before they develop. It may help stop cancer in people who are at high risk due to their genes.
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