Clin2
NCT04921527Possibly a fitRecruiting

Chiauranib with weekly paclitaxel for tough ovarian cancer

Ovarian CancerRelapsed or RefractoryChiauranibPaclitaxel

Treatments studied

Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.

This Phase 3 trial tests whether chiauranib combined with weekly paclitaxel can shrink recurrent ovarian, fallopian tube, or primary peritoneal cancer that did not respond to platinum chemotherapy. It is designed for people who have limited treatment options after platinum-resistant or platinum-refractory disease.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
454 people
Ages
18 years to 70 years
Study type
Interventional

Who can take part

  • You can sign informed consent and you’re age 18–70
  • You have confirmed epithelial ovarian, fallopian tube, or primary peritoneal cancer
  • Your cancer is platinum-refractory or platinum-resistant, and you’ve had no more than 1 prior treatment for recurrence
  • You’re well enough to do daily activities (ECOG 0–1) and have at least one measurable tumor spot
  • Your blood tests, liver/kidney tests, and clotting tests are high enough to start treatment
  • You cannot have used certain medicines recently, including VEGF/VEGFR inhibitors or weekly paclitaxel

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07261683Recruiting· Phase 2
Combination therapy for recurrent ovarian cancer

This trial tests a new combination of chemotherapy, immunotherapy, and a bladder relaxant for ovarian cancer that has come back after initial treatment. It aims to see if adding these drugs together can help control the cancer longer.

Shanghai, Shanghai Municipality
NCT06840002Recruiting· Phase 1/Phase 2
Targeted drug plus chemotherapy for recurrent ovarian cancer

This trial tests a new targeted drug, SHR-A1811, combined with chemotherapy for women whose ovarian cancer has returned but still responds to platinum-based drugs. The goal is to see if the combination works better than chemotherapy alone.

Wuhan, Hubei
NCT06964009Recruiting· Phase 1
New drug plus paclitaxel for resistant ovarian cancer

This trial tests a new drug called DT2216 combined with the chemotherapy drug paclitaxel for ovarian cancer that has stopped responding to platinum-based chemo. The goal is to see if this combination can shrink or slow the cancer, and to find a safe dose.

Boston, Massachusetts
NCT06188455Not yet recruiting· Phase 3
Maintenance therapy after chemo for recurrent ovarian cancer

This trial tests whether a maintenance treatment (fluzoparil and apatinib) can help keep ovarian cancer from coming back after successful platinum-based chemotherapy. It is for women whose cancer either came back within 6 months of their last treatment (platinum-resistant) or more than 6 months later (platinum-sensitive) and who have responded to further chemo.

NCT07214779Recruiting· Phase 3
New drug vs chemo for platinum-resistant ovarian cancer

This study tests a new drug (INCB123667) given as a pill, compared to standard chemotherapy, for people whose ovarian cancer has stopped responding to platinum-based treatments and whose tumor has high levels of a protein called Cyclin E1. The goal is to see if the new drug works better than standard chemo for this specific type of cancer.

Anchorage, Alaska
NCT05636111Recruiting· Phase 1
Study drug lurbinectedin with weekly paclitaxel and bevacizumab

This Phase 1b trial tests how well a new cancer drug (lurbinectedin) works together with weekly paclitaxel and bevacizumab in ovarian, fallopian tube, or peritoneal cancer that has returned or worsened after platinum chemotherapy. It’s designed to find the best way to use these medicines and check for early signs of benefit and safety.

Houston, Texas

Hear when a new Ovarian cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.