Clin2
NCT06188455Possibly a fitNot yet recruiting

Maintenance therapy after chemo for recurrent ovarian cancer

Ovarian Cancer

Treatments studied

Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.

This trial tests whether a maintenance treatment (fluzoparil and apatinib) can help keep ovarian cancer from coming back after successful platinum-based chemotherapy. It is for women whose cancer either came back within 6 months of their last treatment (platinum-resistant) or more than 6 months later (platinum-sensitive) and who have responded to further chemo.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
37 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are a woman aged 18 to 75.
  • You have ovarian, fallopian tube, or primary peritoneal cancer (a type of ovarian cancer).
  • You have received platinum-based chemo before and had a good response, but your cancer has come back—either within 6 months (platinum-resistant) or 6+ months after treatment (platinum-sensitive).
  • You have had at least 4 more cycles of chemo and your disease is stable or shrinking (CR, PR, or SD).
  • You have at least one measurable tumor on a CT scan.
  • You are able to do daily activities with only light effort (ECOG 0–1).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06063070Not yet recruiting· Phase 2
Maintenance treatment for advanced ovarian cancer after first chemotherapy

This study tests a new maintenance therapy for people with advanced ovarian, fallopian tube, or primary peritoneal cancer who have finished their first round of chemo and are showing good response. The goal is to see if this treatment helps delay the cancer from coming back.

Guangzhou, Guangdong
NCT07382713Not yet recruiting· Phase 2
Maintenance therapy after first treatment for advanced ovarian cancer

This trial tests two oral medications given after your first round of chemotherapy. The goal is to see if taking these drugs regularly can keep the cancer from coming back.

NCT07647653Not yet recruiting· Phase 2
Maintenance therapy for advanced ovarian cancer

This trial compares two drug combinations (fluzoparib plus bevacizumab versus olaparib plus bevacizumab) given after initial chemotherapy to keep advanced ovarian cancer from coming back. Participants must have a specific genetic marker (HRD-positive) and have responded well to their first treatment.

NCT05952453Recruiting· Phase 2
New ovarian cancer treatment with chemo plus maintenance medicines

This Phase 2 trial tests giving chemotherapy before surgery, then continuing two medicines afterward (olaparib and pembrolizumab). It’s designed for people with newly diagnosed Stage III/IV ovarian, fallopian tube, or primary peritoneal cancer who may benefit from tighter control of the disease.

Birmingham, Alabama
NCT05255471Recruiting· Phase 3
Olaparib after surgery for recurrent ovarian cancer

This trial tests whether olaparib (a pill cancer medicine) works better than standard platinum chemotherapy after a second surgery for recurrent ovarian cancer. It’s for people whose cancer returned after initial PARP-inhibitor (PARPi) maintenance and aims to see if treatment can control the cancer for longer with acceptable side effects.

Naples
NCT06971744Recruiting· Phase 2
Study of autophagy maintenance for ovarian cancer

This trial tests whether a combination of medications (hydroxychloroquine, everolimus, and others) can help keep ovarian cancer from coming back after successful platinum chemotherapy plus Avastin. It is for people whose cancer responded well to their most recent chemo and who can continue Avastin maintenance.

Charleston, South Carolina

Hear when a new Ovarian cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.