Obeticholic acid to prevent Barrett’s esophagus worsening
Part of Cancer, Digestive system clinical trials.
This Phase 2 trial tests whether obeticholic acid (a medicine) can help stop Barrett’s esophagus from getting worse. You must already be taking acid-suppressing medicine and have non-cancer Barrett’s changes, and the study checks safety and whether the lining improves or stays stable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have Barrett’s esophagus confirmed by biopsy, showing no dysplasia, indefinite dysplasia, or low-grade dysplasia
- Your biopsy/endoscopy must show Barrett’s tissue involvement of at least 2 cm, and at least one biopsy has 50% intestinal metaplasia
- You’ve been taking a proton pump inhibitor (PPI) for at least 28 days
- You’re 18 years or older, and you can sign consent and follow study instructions
- Your blood counts and organ tests (kidneys and liver) meet safety thresholds
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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