Stronger acid-reducing pill for Barrett's esophagus
Part of Cancer, Digestive system clinical trials.
This trial tests a newer, stronger type of acid-reducing pill (called a PCAB) to see if it controls acid better than the usual medicines for people with Barrett's esophagus. The goal is to reduce acid exposure that can lead to further damage.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older
- You must have a history of acid reflux (GERD) - it's okay if you don't have heartburn symptoms
- You must have Barrett's esophagus confirmed by an endoscopy (a camera test) within the last 3 years, with a segment at least 2 cm long
- A recent biopsy must show no precancerous changes (no dysplasia)
- You must be currently taking a daily acid reducer (like omeprazole or esomeprazole) for at least 3 months
- You cannot have had certain stomach or esophagus surgeries, or have certain conditions like a pacemaker or bleeding problems
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 trial tests whether obeticholic acid (a medicine) can help stop Barrett’s esophagus from getting worse. You must already be taking acid-suppressing medicine and have non-cancer Barrett’s changes, and the study checks safety and whether the lining improves or stays stable.
This trial tests a device that collects cells from the esophagus using a swallowed capsule, which may detect Barrett's esophagus without a standard endoscopy. It is for people who are already scheduled for an endoscopy.
This study compares two approaches for people with Barrett's esophagus and low-grade dysplasia: regular surveillance (monitoring with endoscopies) versus endoscopic treatment to remove the abnormal cells. It aims to see which approach is better at preventing progression to more serious conditions.
This study looks for signs of Barrett's esophagus in people with GERD (chronic acid reflux). It uses an endoscopy to check the esophagus, which may help catch early changes that could lead to cancer.
This trial compares two ways to choose the best treatment for people with frequent acid reflux. It tests whether using a simple test (called PCAB-guided) is as good as a more detailed test (called physiologic test-guided) for deciding on the right medicine. The goal is to find a more practical and effective approach.
This study tests whether taking a bile acid pill (ursodeoxycholic acid) during treatment for Barrett's esophagus can help the esophagus heal better after standard endoscopic therapy. It may reduce the chance of precancerous cells returning.
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