Itraconazole with ablation to prevent esophageal cancer in Barrett's esophagus
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests if adding the antifungal drug itraconazole to standard ablation therapy can help prevent esophageal cancer in people with high-risk Barrett's esophagus. You must have a confirmed diagnosis of Barrett's esophagus with low- or high-grade dysplasia or early-stage cancer, and be planning to have ablation treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have Barrett's esophagus (at least 2 cm long) with low- or high-grade dysplasia or stage T1a esophageal cancer, and have not had previous treatment
- You are 18 years or older
- Your blood counts, liver, and kidney function are within safe limits (tests will be done to check)
- You do not have serious heart problems, such as heart failure or a long QT interval on an EKG
- You are not pregnant, breastfeeding, or planning to become pregnant; you must use effective non-estrogen birth control during and 2 months after the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 trial tests whether obeticholic acid (a medicine) can help stop Barrett’s esophagus from getting worse. You must already be taking acid-suppressing medicine and have non-cancer Barrett’s changes, and the study checks safety and whether the lining improves or stays stable.
This study tests whether adding itraconazole (an anti-fungal medicine) to standard chemo-radiation before surgery increases the chance of complete tumor response. It’s for people with esophageal (or GE junction) cancer that can be removed with curative surgery after treatment.
This study looks at how radiofrequency ablation (RFA) affects the flexibility and lining of the esophagus in people with Barrett's esophagus and early cancer. It may help doctors understand how this treatment works.
This trial tests two simple, non-surgical methods to look for Barrett's esophagus (a change in the lining of the swallowing tube) and early esophageal cancer. It is for people who are at higher risk or lower risk, but have never had Barrett's or cancer before.
This study tests a new, less invasive way to detect precancerous changes or early cancer in Barrett's esophagus. It uses a sponge or brush to collect cells from your esophagus during a routine endoscopy, which may help find problems earlier and avoid more invasive procedures.
This trial tests a new risk model to predict if early Barrett's esophagus-related cancer may return. It also looks at how telling patients their risk affects their quality of life and fear of cancer. If you have Barrett's with a small, early cancer, this study may help decide the best follow-up plan for you.
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