Chemo-immunotherapy before surgery versus chemo-radiation
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial compares adding immunotherapy to standard chemo-radiation before surgery for locally advanced, operable esophageal squamous cell cancer. It aims to improve how well the tumor responds and whether patients do better after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have esophageal squamous cell cancer confirmed by pathology, using a sample taken before treatment
- Your tumor is in the chest (thoracic part of the esophagus) and is considered operable stage II–III
- You are age 18 to 75 and can function fairly well (ECOG 0–1) with an expected survival of at least 12 months
- Your heart, lungs, bone marrow, liver, and kidneys must meet lab/test thresholds (including a breathing test and ECG)
- You can sign consent and follow the study plan
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests giving a combination of chemotherapy, radiation therapy, and an immunotherapy drug before surgery for a type of esophageal cancer (squamous cell). The goal is to see if this approach helps shrink the tumor and improve outcomes for patients whose cancer can be surgically removed.
This trial tests whether giving chemotherapy combined with immunotherapy before surgery works better than the standard chemoradiation for esophageal cancer that can be removed. It may help reduce tumor size and improve outcomes.
This trial studies giving immunotherapy (anti–PD-1) together with chemotherapy before surgery for certain locally advanced esophageal squamous cell cancer. The goal is to improve how well the tumor responds before and after the operation.
This trial tests a drug called Adebrelimab combined with chemotherapy before surgery for esophageal cancer. It aims to shrink the tumor and make it easier to remove completely.
This trial tests a treatment plan that combines chemotherapy and immunotherapy before surgery, followed by radiation and immunotherapy after surgery for people with esophageal squamous cell cancer. It aims to see if this approach helps prevent the cancer from coming back.
This Phase 3 trial tests whether adding immunotherapy to chemotherapy before surgery works better than chemotherapy alone for resectable esophageal cancer. The goal is to improve outcomes after tumor shrinkage before the operation.
Hear when a new Esophageal Squamous Cell Carcinoma Stage II trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.