Clin2
NCT04973319Possibly a fitNot yet recruiting

Trastuzumab and pertuzumab after surgery for HER2-positive breast cancer

Breast Cancer

Treatments studied

Part of Cancer, Skin clinical trials.

This study tests a new combination of two HER2-targeted drugs (trastuzumab and pertuzumab) given after surgery for HER2-positive breast cancer. It looks at whether this combination can help reduce the risk of cancer coming back in people who still had some cancer left after neoadjuvant therapy.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
450 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are a woman between the ages of 18 and 75.
  • You were diagnosed with HER2-positive breast cancer and had surgery after neoadjuvant therapy (treatment before surgery).
  • After surgery, there was still some cancer left in the breast or lymph nodes.
  • You have already completed at least 8 cycles (about 24 weeks) of treatment with trastuzumab and pertuzumab after surgery.
  • Your last dose of trastuzumab was within the past year.
  • You must be in generally good health and have normal heart, liver, and blood counts.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07047755Not yet recruiting· Phase 2
Trastuzumab rezetecan with pertuzumab before surgery for HER2-positive breast cancer

This trial tests a combination of two targeted therapies given before surgery to shrink HER2-positive breast cancer tumors. The goal is to see if this approach is safe and effective for early-stage breast cancer.

NCT05841381Not yet recruiting· Phase 3
Combining two targeted drugs after surgery for early HER2-positive breast cancer

This trial tests whether adding the targeted drug pyrotinib to the standard HER2-targeted medicine trastuzumab after surgery can help lower the chance of early-stage HER2-positive breast cancer coming back.

NCT05292742Recruiting· Phase 2
Continue targeted breast cancer therapy or switch to a new combo

This Phase 2 study compares two treatment plans after breast surgery when cancer did not fully disappear before surgery. It tests whether adding trastuzumab, pyrotinib, and capecitabine works better than continuing the original targeted therapy.

Fuzhou, Fujian
NCT05891561Recruiting· Phase 2
Short antibody treatment after surgery for early HER2+ breast cancer

This Phase 2 study tests a shorter schedule of trastuzumab and pertuzumab combined with chemotherapy (taxanes) to reduce breast cancer coming back after surgery. It mainly helps people with early-stage, HER2-positive breast cancer that has not spread, by testing whether a shorter plan still works well and is tolerable.

Shanghai, Shanghai Municipality
NCT06483386Not yet recruiting· Phase 2
Pre-surgery combination therapy for her2-positive breast cancer

This trial tests a combination of two targeted drugs (pyrotinib and trastuzumab) plus chemotherapy (capecitabine) before surgery for women with early-stage HER2-positive breast cancer. The goal is to shrink the tumor and improve treatment outcomes.

NCT06000917Recruiting· Phase 2
Study of combination therapy before surgery for ER+/HER2+ breast cancer

This trial tests a combination of targeted therapies and chemotherapy given before surgery for women with a specific type of breast cancer that is both ER-positive and HER2-positive. The goal is to see if this treatment can shrink tumors and improve outcomes.

Wuhan, Hubei

Hear when a new Breast cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.