Clin2
NCT04999228Possibly a fitRecruiting

Top-down versus step-up treatment for pediatric ulcerative colitis

Ulcerative ColitisInfliximabChildren

Treatments studied

Part of Digestive system clinical trials.

This trial compares two treatment approaches for children newly diagnosed with ulcerative colitis: starting with stronger medicines right away versus beginning simpler and stepping up if needed. It may help your child learn which strategy controls symptoms better with fewer flare-ups.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
40 people
Ages
6 years to 18 years
Study type
Interventional

Who can take part

  • Your child is 6 to 18 years old
  • Your child has newly diagnosed ulcerative colitis
  • Your child currently has moderate to severe disease activity
  • Your child does NOT have only mild disease activity
  • Your child has not already been treated with steroid medicines for ulcerative colitis
  • Your child has not already been treated with biologic medicines for ulcerative colitis

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05043870Recruiting· Phase 4
Testing medicines that calm the immune system in kids with Crohn’s

This trial studies a combination of immune-suppressing treatments for children with Crohn’s disease that is not well controlled. It may help reduce inflammation and improve symptoms if you meet the study’s disease-activity and safety requirements.

Shanghai, Shanghai Municipality
NCT06614387Not yet recruiting· Phase 3
Comparing vedolizumab and infliximab for pediatric ulcerative colitis

This study compares two biologic medicines, vedolizumab and infliximab, to see which works better for children with moderate to severe ulcerative colitis. It aims to find a more effective treatment to reduce symptoms and improve quality of life.

NCT06453317Recruiting· Phase 2
Comparing UC treatments: infliximab vs ustekinumab vs both

This study compares an existing UC medication (infliximab) with a newer one (ustekinumab) and a combination of both. The goal is to see which works best for moderate to severe UC when other treatments have failed.

Lodz
NCT04314375Recruiting· Phase 4
Budesonide tablets for children with mild to moderate ulcerative colitis

This trial studies whether budesonide extended-release tablets are safe and effective for improving symptoms in children ages 5–17 with active, mild to moderate ulcerative colitis. It also measures how the medicine moves through the body.

Garden Grove, California
NCT05679622Recruiting
Stool transplant study for children with mild to moderate ulcerative colitis

This trial studies whether transferring healthy stool bacteria into the gut (fecal microbiota transplantation, or FMT) can improve symptoms in children with ulcerative colitis. It may help by changing gut bacteria, especially for children who are newly diagnosed or who didn’t respond to standard treatments.

Wuhan
NCT06954311Recruiting
Drug monitoring for children with IBD

This study monitors levels of certain medications (infliximab, adalimumab, vedolizumab, ustekinumab) in children with inflammatory bowel disease to see if adjusting the dose helps them feel better. It aims to improve treatment outcomes.

Feldkirch

Hear when a new Ulcerative Colitis trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.