Testing venetoclax and gilteritinib with ASTX727 for FLT3 leukemia
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This Phase 1/2 trial tests a combination of medicines (ASTX727, venetoclax, and gilteritinib) for adults with FLT3-mutated acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). It aims to see how well the treatment works and how safe it is for people whose disease has come back, is not responding, or (for some) is newly diagnosed.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 or older and have AML or high-risk MDS with an FLT3 mutation
- Your disease risk level is intermediate-2 or high-risk (for the specific trial group)
- You can take the study pills by mouth (you’re able to swallow)
- Your heart, liver, and kidney labs are within limits, unless the doctor says they’re caused by your leukemia
- You’re not in the trial if you have certain major infections, uncontrolled serious heart failure, or leukemia in the brain/spinal fluid
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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