Buprenorphine plus naltrexone shot to prevent opioid relapse
Treatments studied
Part of Mental health clinical trials.
This trial tests whether a combination of buprenorphine (through your care plan) and a monthly extended-release naltrexone (XR-NTX) shot can help prevent opioid relapse. It may help people who are ready to move toward a naltrexone-based relapse-prevention treatment after detox.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be age 18 to 65 and want relapse-prevention treatment for opioid use disorder
- Have opioid use disorder for at least 6 months, with recent opioid evidence on urine testing (or you recently completed detox/induction)
- Have completed opioid detox and received XR-NTX, or can start XR-NTX induction within 2 weeks of a previous XR-NTX injection
- Be medically healthy enough for study procedures (physical exam, blood/urine tests, ECG) with no major abnormal results
- Be able and willing to sign consent and understand the difference between “agonist” and “antagonist” treatment
- Agree you are a good candidate for naltrexone-based treatment (your clinician’s judgment)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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