Test drug after early HER2-positive breast cancer surgery
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests zanidatamab, a type of targeted antibody treatment, in people with early-stage HER2-positive breast cancer to see how well it works and how safe it is. Because it’s a single-arm pilot study, everyone in the study gets the drug, and you’ll likely be asked to undergo standard surgery if appropriate.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re an adult (over 18) and can sign informed consent
- Your cancer is early-stage HER2-positive breast cancer with no spread to lymph nodes or distant organs
- Your tumor is larger than 1 cm but not bigger than 3 cm based on scans
- Your heart test (echocardiogram or MUGA) is within normal limits
- Blood tests and organ function are strong enough (enough blood cells, liver/kidney function within limits)
- You can (and will) use effective birth control, or you’re not able to have children
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new drug called zanidatamab combined with chemotherapy to shrink HER2-positive breast cancer before surgery. It may help improve treatment outcomes for people with stage 2 or 3 breast cancer that has not spread.
This trial tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein (called HER2-positive). It aims to see if zanidatamab can shrink or slow the growth of these tumors.
This trial is testing a combination of two targeted drugs (zanidatamab and tucatinib) plus chemotherapy for people with HER2-positive breast cancer that has spread or cannot be removed by surgery. It's for those who have already had at least one other anti-HER2 treatment but no more than three.
This trial tests a combination of targeted therapies (trastuzumab and pertuzumab) with chemotherapy (docetaxel) and an experimental drug (QL1706) given before surgery to shrink early or locally advanced HER2-positive breast cancer. It aims to see if this approach improves outcomes before definitive surgery.
This trial tests if a newer drug, Trastuzumab Rezetecan, works as well as an approved drug, Trastuzumab Deruxtecan, when given before surgery for HER2-positive breast cancer. It aims to see which one helps shrink tumors more effectively.
This trial tests a targeted therapy (anti-HER2) given before and after surgery for Nigerian women with HER2-positive breast cancer. It aims to see if this treatment helps shrink tumors and improve outcomes.
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