Test DNA blood and tissue markers to detect gynecologic cancers
Treatments studied
Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This study looks for “methylated DNA markers” (special DNA patterns) to help detect endometrial, ovarian, and cervical cancers, and to support doctors around planned procedures. It may help find cancer earlier or better sort out who needs closer treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a patient at least 18 years old (or 45+ for some parts of the study)
- You have a reason for evaluation (abnormal bleeding, abnormal Pap/colposcopy, a cervical mass, or a planned surgery for gynecologic issues)
- For some groups: you must have a biopsy-confirmed or strongly suspected cancer or precancer
- You must NOT be pregnant, and you must not have had a prior hysterectomy (in most groups)
- You must NOT have had pelvic/vaginal radiation, and recent chemotherapy/radiation can disqualify you
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests two less invasive methods—sampling cells from the lining of the uterus (endometrial cytology) and checking DNA changes in the cervix—to see if they can help detect endometrial cancer or atypical hyperplasia, and to monitor response in people who are preserving their fertility. It aims to find a gentler alternative to traditional biopsy.
This study tests if a DNA test in urine and vaginal samples you collect at home can help find endometrial cancer. It compares results from people with the cancer to healthy volunteers.
This study looks at combining genetic testing with surgical exams to better understand endometrial cancer. It may help doctors see which treatments could work best for you.
This study uses a risk model to detect endometrial cancer in people with unexplained abnormal uterine bleeding. It aims to find better ways to identify cancer early without relying only on invasive biopsies.
This study tests a simple, non-invasive method to detect endometrial cancer in women after menopause who have abnormal bleeding. It aims to find cancer early in those at higher risk, such as women with certain genetic conditions or risk factors.
This trial tests whether a blood test for ctDNA (cancer DNA fragments) can help doctors decide if standard chemotherapy plus an immunotherapy drug is working for people with advanced or recurrent endometrial cancer. It may help tailor your treatment based on how the cancer responds.
Hear when a new Endometrial Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.