Gabapentin for bipolar symptoms with heavy cannabis use
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy, Mental health clinical trials.
This Phase 2 study tests whether gabapentin can help balance brain chemicals (GABA and glutamate) in people with bipolar disorder and cannabis use disorder. If you meet criteria, you may be able to try gabapentin while closely monitoring mood, safety, and cannabis use.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 to 65 years old
- Have moderate to severe cannabis use disorder in the past 3 months and cannabis is your main substance (positive urine test)
- Have bipolar I or bipolar II (or bipolar-type schizoaffective) diagnosed by DSM-5
- Take at least one mood stabilizer every day (like lithium, valproate, lamotrigine, carbamazepine, or a second-generation antipsychotic)
- Be able to consent and complete study questionnaires, and commit to medication and follow-up visits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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