Clinical trials
Bipolar Disorder clinical trials
Below are recruiting bipolar disorder clinical trials, each written for real people, not researchers. We’re tracking 185 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06229210RecruitingPhase 3
Lumateperone safety study for children with schizophrenia, bipolar, or autism
This trial tests a medication called lumateperone for children and teens with schizophrenia, bipolar disorder, or autism spectrum disorder. It aims to see if the medicine is safe and tolerable over time.
Phoenix, ArizonaAges 5–17 - NCT05669703Recruiting
Tracking mood and activity patterns in bipolar disorder families
This study watches how a person’s mood and movement change over time, and how those patterns relate to bipolar disorder. It may help researchers better understand the condition in families and potentially improve future care.
Bethesda, MarylandAges 8–70 - NCT05828056Recruiting
Predicting mood episodes in bipolar disorder with a smartwatch
This study uses a smartwatch and smartphone to track daily patterns and predict when manic or depressive episodes might happen in people with bipolar disorder. It aims to help patients and doctors better manage the condition.
TaipeiAges 20–60 - NCT06706232RecruitingPhase 2
Psilocybin for Depression and Suicidal Thoughts in Bipolar II
This trial tests if two doses of psilocybin, given under medical supervision, are safe and acceptable for people with Bipolar II disorder who have mild to moderate depression and certain suicidal thoughts. The goal is to see if it may help improve mood and reduce suicidal thinking.
Houston, TexasAges 25–70 - NCT05934474Recruiting
Study collects blood to learn about inflammation in mental illness
This study collects biological samples to better understand how “inflammation” in the body may relate to certain mental health conditions. Your results may help doctors learn more about causes and future treatments, even if the study does not give a new drug.
NantesAges 18 years+ - NCT07569198RecruitingPhase 2
Ketamine plus therapy for depression with suicidal thoughts
This study tests whether ketamine (a medication) combined with a specific type of therapy called DBT can help people with treatment-resistant depression and borderline personality disorder who are having thoughts of suicide. You would receive ketamine infusions alongside structured therapy sessions over 6 months.
Toronto, OntarioAges 18–70 - NCT03829787Recruiting
Study of attention and reward signals in bipolar disorder
This study looks at how people with bipolar disorder pay attention and respond to rewards, including whether anxiety or substance use is also present. It uses eye-tracking and related tests to better understand brain patterns that may affect mood and decision-making.
Cleveland, OhioAges 18 years+ - NCT04230421Recruiting
Smartphone treatment program for bipolar disorder
This trial is testing a smartphone-based treatment approach for people living with bipolar disorder. It may help by delivering support and care tools in a way that’s easier to use day to day.
CopenhagenAges 18 years+ - NCT04480918Recruiting
Registry for people with depression or bipolar to receive psychiatry care
This is a patient registry that enrolls people being evaluated for treatment options from an Interventional Psychiatry Service. It helps track patients with depression, bipolar disorder, or treatment-resistant OCD who are suitable for these psychiatry treatments.
Iowa City, IowaAges 18–99 - NCT05025605RecruitingPhase 1
Study medicine for agitation in youth with bipolar or schizophrenia
This Phase 1 trial tests whether BXCL501 is safe and can help reduce agitation in children and teens who have bipolar disorder or schizophrenia. You may be considered if your agitation is significant during screening, but certain recent medication and health factors can make you ineligible.
Anaheim, CaliforniaAges 10–17 - NCT05153382Recruiting
Dialectical behavior therapy for youth at bipolar risk
This trial tests whether a structured therapy called dialectical behavior therapy (DBT) helps young people with bipolar disorder or at risk for it, especially with self-harm or risky behaviors. It may help by teaching coping skills and improving safety and emotional control.
Toronto, OntarioAges 13–23 - NCT05427123Recruiting
Study for kids and teens with bipolar or cyclothymic disorder
This trial is testing treatments for children and teens (ages 9–19) who have been diagnosed with bipolar disorder or cyclothymic disorder. It also requires regular participation from a caregiver so the team can track symptoms and response over time.
Los Angeles, CaliforniaAges 9–19 - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT05627492Recruiting
DBT booster sessions for youth at bipolar risk
This study adds short “booster” sessions to Dialectical Behavior Therapy (DBT) for young people who already took part in a prior DBT study, including those with bipolar symptoms or strong family risk. It aims to see if extra DBT support helps mood and coping over time.
Toronto, OntarioAges 14–25 - NCT05802446Recruiting
Neurofeedback program for bipolar depression symptoms
This study tests whether “neurofeedback” can reduce leftover (residual) depressive symptoms in people with bipolar I or II. It may help calm mood by training brain activity, alongside stable medication.
Créteil, val-de-marneAges 18–65 - NCT06204705Recruiting
App to Predict Bipolar Episodes in Veterans
This study uses a smartphone app to track your mood and daily habits and predict when a bipolar episode might be coming. The goal is to help you and your care team take action early to prevent a full episode.
Minneapolis, MinnesotaAges 18 years+ - NCT06221852Recruiting
Ketogenic diet for first episode bipolar disorder
This study tests whether a special high-fat, low-carbohydrate diet (ketogenic diet) can help people who have recently been diagnosed with bipolar disorder. It may improve mood stability and overall brain health.
Belmont, MassachusettsAges 18–45 - NCT06226025RecruitingPhase 2
Melatonin for Bipolar Disorder in Night Owls
This trial tests whether giving melatonin at the right time can help people with bipolar disorder who are night owls improve their mood and sleep. You would take melatonin or a placebo each evening for a few weeks while tracking your symptoms on a phone app.
Ann Arbor, MichiganAges 18–60 - NCT06274567Recruiting
Brain stimulation for emotion in bipolar depression
This study tests a safe, non-invasive brain stimulation technique called iTBS to see if it can help people with bipolar disorder better manage their emotions during a depressive episode. It may offer a new option for those who are still feeling depressed despite stable medication.
Charlestown, MassachusettsAges 24–65 - NCT06370988Recruiting
Theta-burst stimulation for bipolar depression
This study tests a type of brain stimulation (theta-burst TMS) to see if it helps improve depression in people with bipolar disorder. It might be a good option if you have tried medication but still feel depressed.
Toronto, OntarioAges 18–65 - NCT06373016Recruiting
Ketone drink study for stable bipolar disorder
This study tests whether a ketone drink can change how the body uses energy in people with bipolar disorder. It may help understand new ways to manage the condition.
Belmont, MassachusettsAges 18–45 - NCT06384755Recruiting
Honest Open Proud for psychosis and bipolar disorder
This study tests a program called Honest, Open, Proud to help people with psychosis or bipolar disorder deal with stigma and decide whether to share their diagnosis. It aims to reduce shame and improve confidence.
OsloAges 18–65 - NCT06488573Recruiting
Nutrition program to improve heart health in bipolar disorder
This study tests if a nutrition program can help people with bipolar disorder improve their heart health. It is for adults aged 18 to 60 with bipolar I or II who are already on medication and are at moderate or high risk for heart problems.
São Paulo, São PauloAges 18–60 - NCT06497868Recruiting
Self-compassion and bipolar disorder
This study looks at how self-compassion (being kind to yourself) relates to bipolar disorder. If you have bipolar disorder and have been treated outside a hospital in recent years, you may be able to help by allowing researchers to review your medical records.
Strasbourg, Les Hôpitaux Universitaires de StrasbourgAges 18 years+
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Bipolar Disorder trials by city
Studies with a site in or near these metro areas.
Bipolar Disorder trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for bipolar disorder?
- Yes. Clin2 currently lists 185 recruiting bipolar disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.