Fecal transplant plus fiber for gut graft-versus-host disease
Treatments studied
Part of Digestive system, Immune system & allergy clinical trials.
This Phase 1 study tests whether a fecal microbiota transplant (a stool-based treatment from a screened donor) plus a dietary fiber supplement can improve gut symptoms after a bone marrow transplant. It is aimed at people with mild to severe gut graft-versus-host disease (GVHD).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You had an allogeneic bone marrow stem cell transplant in the last 12 months
- Your neutrophil blood counts have recovered after transplant (a specific lab timing requirement)
- You have mild to severe acute gut GVHD confirmed by symptom criteria or biopsy
- You can follow the study plan, including taking the fiber, doing stool sample collection, and undergoing colonoscopy
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a fecal transplant (FMT) can help treat gut graft-versus-host disease (gut GVHD), a condition where donated immune cells attack the intestines. If you have gut GVHD and meet age requirements, you may be eligible to receive this treatment in the trial.
This study tests if a fecal transplant (transferring healthy bacteria from a donor's stool into your gut) can help people with severe gut graft-versus-host disease that hasn't responded to steroids. It's for patients who have had a stem cell transplant and now have ongoing, severe gut symptoms.
This study tests whether restoring healthy gut bacteria using a fecal microbiota transplant can improve steroid-refractory gut graft-versus-host disease (aGvHD) after stem cell transplant. If your gut symptoms are your first episode and your stool bacteria diversity is low, this trial may be an option worth screening for.
This Phase 2 study tests whether a fecal microbiota transplant (a processed transplant of gut bacteria) after an allogeneic bone marrow transplant is safe and helpful. Participants may benefit by improving recovery in the gut microbiome during the post-transplant period.
This study tests whether transplanting healthy donor stool into the gut can help children and young adults with ongoing digestive issues after a stem cell transplant. It may improve symptoms like diarrhea or the need for feeding tubes.
This trial tests whether transplanting healthy gut bacteria can help children whose bodies are rejecting donor stem cells in their intestines and who haven't responded to high-dose steroids. The goal is to reduce intestinal damage and improve outcomes after bone marrow transplant.
Hear when a new Intestinal Graft Versus Host Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.